{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:14Z","timestamp":1792395854161,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic stem cell transplantation (HSCT) is a cornerstone therapy for haematological and genetic disorders. Owing to the limited availability of HLA\u2010identical related donors, umbilical cord blood (UCB) has become a valuable alternative source of haematopoietic progenitors. However, many UCB units are excluded from banking based on quality criteria, despite potentially harbouring rare and underrepresented HLA profiles, particularly within certain demographic groups. This study evaluated the strategic value of immunogenetically rare but low\u2010quality UCB units in expanding donor options for patients with uncommon HLA profiles.\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    ,\n                    <jats:italic>\u2010B,<\/jats:italic>\n                    and\n                    <jats:italic>\u2010DRB1<\/jats:italic>\n                    typing was performed on 577 UCB units, and allelic, haplotypic, and genetic diversity analyses were conducted using the HLA\u2010net GENE[RATE] tool. Units were categorised using the Search Prognosis Application as good (6\/6), fair (5\/6), or poor (&lt;\u20095\/6 matches). Genotype frequency was used as a proxy for immunogenetic rarity and evaluated as an operational criterion for defining retention thresholds. ROC analyses were interpreted as concordance analyses between genotype frequency and Search Prognosis classification rather than as independent predictive validation. Statistical significance was assessed by chi\u2010square and residual analyses. The cohort displayed remarkable allelic diversity, particularly at the\n                    <jats:italic>HLA\u2010B<\/jats:italic>\n                    locus, strong linkage disequilibrium among loci, and a large proportion of unique genotypes. Matching\u2010prognosis classification identified 66.72% of units as good, 31.54% as fair, and 1.73% as poor. Caucasian genotypes were overrepresented in the good category, whereas Asian\u2010Pacific\u2010Islander and African\u2010American haplotypes were enriched in poorer matching\u2010prognosis categories. ROC analysis showed strong concordance between genotype frequency and Search Prognosis classification (AUC 0.80\u20130.99) and population\u2010specific genotype frequency thresholds. Our findings suggest that immunogenetic rarity provides complementary value to conventional quality metrics. While low\u2010cell\u2010dose units may have limited direct clinical utility, those with rare HLA genotypes may retain strategic importance, particularly for patients with uncommon immunogenetic profiles. Integrative approaches combining biological and immunogenetic parameters may improve cord blood banking strategies.\n                  <\/jats:p>","DOI":"10.1111\/tan.70817","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:59:49Z","timestamp":1783151989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of Genetically Rare Cord Blood Units Beyond Conventional Quality Metrics"],"prefix":"10.1111","volume":"108","author":[{"given":"Estela","family":"Selma\u2010Soriano","sequence":"first","affiliation":[{"name":"Transfusion Center of the Valencian Community  Valencia Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO)  Valencia 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