{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:16Z","timestamp":1792395856066,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Luminex bead\u2010based immunoassays are central to HLA antibody testing in histocompatibility laboratories, yet QC monitoring remains largely manual. Although ISO 15189, EFI and ASHI standards require statistical trend analysis, laboratories typically rely on spreadsheet tracking or periodic visual inspection; these approaches can detect gross run failures but are poorly suited to surfacing gradual trends in instrument, reagent and operator performance. We developed BeadWatch, an open\u2010source automated QC dashboard application that reads directly from vendor databases, applies Levey\u2010Jennings charts with optional I\u2010MR views, and includes cross\u2010instrument and cross\u2010operator comparison dashboards and configurable alerting. BeadWatch currently supports OneLambda HLA Fusion and deploys as a single portable application with no installation steps. Single\u2010site deployment in our laboratory ingested approximately 20\u2009years of historical data, revealing instrument lifecycle trajectories and a step change in instrument MFI following a platform transition\u2014patterns consistent with known instrument behaviour but not previously documented. During prospective monitoring, an automated alert identified a pipetting error before the responsible operator had independently recognised the issue. BeadWatch is freely available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/github.com\/oxfordgenes\/BeadWatch\">https:\/\/github.com\/oxfordgenes\/BeadWatch<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/tan.70849","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:11:07Z","timestamp":1783685467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BeadWatch<\/scp>\n                    : Automated Longitudinal Quality Control Monitoring for Luminex Bead\u2010Based Immunoassays in Histocompatibility Laboratories"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-4861","authenticated-orcid":false,"given":"Mian","family":"Chen","sequence":"first","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Docker","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Williams","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Cutland","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Quirno","family":"Costa","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C. N.","family":"Barnardo","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351459"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31827a19cc"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.06.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200301150\u201000008"},{"key":"e_1_2_10_6_1","volume-title":"ISO 15189:2022: Medical laboratories\u2014Requirements for Quality and Competence","author":"International Organization for Standardization","year":"2022"},{"key":"e_1_2_10_7_1","volume-title":"Standards for Histocompatibility and Immunogenetics Testing (EFI) v8.1","author":"European Federation for Immunogenetics","year":"2024"},{"key":"e_1_2_10_8_1","volume-title":"Standards for Accredited Laboratories (ASHI 2025)","author":"American Society for Histocompatibility and Immunogenetics","year":"2026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12807"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.05.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/20.11_ts.1059"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/27.3.493"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201057652\u20104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00294\u201012"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.70849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.70849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.70849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:21:30Z","timestamp":1792394490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.70849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/tan.70849"],"URL":"https:\/\/doi.org\/10.1111\/tan.70849","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70849"}}