{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:21:20Z","timestamp":1787732480512,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404304"],"award-info":[{"award-number":["2023YFC3404304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3406800"],"award-info":[{"award-number":["2024YFC3406800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Swine leukocyte antigens (SLA) may be a new type of xenoantigen. Previous studies on SLA have primarily focused on their cross\u2010reactivity with HLA. However, the role of SLA in stimulating xenogeneic immune responses after xenotransplantation remains unclear. In our recent kidney xenotransplantation study in rhesus monkeys using GTKO\/hCD55 or GTKO\/\u03b24GalNT2KO\/hCD55\/hTBM pigs as donors, 5 of 13 recipients experienced early AMR accompanied by a marked increase in anti\u2010donor pig antibodies. Flow cytometry analysis showed that the terminal sera of these recipients contained significant de novo anti\u2010SLA antibodies, as evidenced by reduced antibody binding to GTKO\/SLA\u2010I\/II KO pig PBMCs. Using GTKO\/\u03b24GalNT2KO pAECs with or without pIFN\u2010\u03b3 stimulation as target cells, we found that the binding levels of the terminal sera to pAECs were positively correlated with SLA expression. IP\u2010MS analysis identified multiple SLA class I and class II epitopes targeted by recipient IgG antibodies, with SLA\u20102 emerging as a dominant immunogenic antigen. In addition, xenogeneic MLR assays revealed that deletion of SLA, particularly SLA class II, markedly attenuated human anti\u2010pig T\u2010cell proliferation. These results demonstrate that induced anti\u2010SLA antibodies can be generated in the early period after pig\u2010to\u2010monkey kidney xenotransplantation and may play a significant role in the development of AMR.<\/jats:p>","DOI":"10.1111\/tan.70894","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:31:51Z","timestamp":1785810711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibody Responses Against Swine Leukocyte Antigens Contribute to Early Rejection After Pig\u2010To\u2010Monkey Kidney Xenotransplantation"],"prefix":"10.1111","volume":"108","author":[{"given":"Hao","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Organ Transplantation, Ministry of Education  Wuhan China"},{"name":"NHC Key Laboratory of Organ Transplantation  Wuhan China"},{"name":"Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Organ Transplantation, Ministry of Education  Wuhan China"},{"name":"NHC Key Laboratory of Organ Transplantation  Wuhan China"},{"name":"Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3798-284X","authenticated-orcid":false,"given":"Jiaxiang","family":"Du","sequence":"additional","affiliation":[{"name":"Chengdu Clonorgan Biotechnology Co. 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