{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:29Z","timestamp":1792140329608,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306216\/2025\u20106"],"award-info":[{"award-number":["306216\/2025\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The HLA system has been extensively studied due to its crucial role in the immune system, as well as its application in population, anthropological and epidemiological research. This study analysed 11\n                    <jats:italic>loci<\/jats:italic>\n                    of HLA allele and haplotype frequency (HLA\u2010A, \u2010B, \u2010C, \u2010DRB1, \u2010DQA1, \u2010DQB1, \u2010DPA1, \u2010DPB1 and \u2010DRB3\/4\/5) using high\u2010resolution next\u2010generation sequencing technology. A total of 5287 volunteer bone marrow donors from the Northwestern region of the state of Paran\u00e1, in Southern Brazil, were rated. Most of the analysed\n                    <jats:italic>loci<\/jats:italic>\n                    were in Hardy\u2013Weinberg equilibrium, except for HLA\u2010DPA1 and \u2010DPB1. The most frequent alleles were\n                    <jats:italic>HLA\u2010A*02:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>HLA\u2010B*51:01:01<\/jats:italic>\n                    and\n                    <jats:italic>HLA\u2010C*04:01:01<\/jats:italic>\n                    for Class I and\n                    <jats:italic>DRB1*07:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB3*02:02P<\/jats:italic>\n                    ,\n                    <jats:italic>DRB4*01:01P<\/jats:italic>\n                    ,\n                    <jats:italic>DRB5*01:01P<\/jats:italic>\n                    ,\n                    <jats:italic>DQA1*01:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQB1*05:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>DPA1*01:03:01<\/jats:italic>\n                    and\n                    <jats:italic>DPB1*04:01:01<\/jats:italic>\n                    for Class II. The most prevalent haplotype for ABCDRB1 alleles was\n                    <jats:italic>HLA\u2010A*01:01:01<\/jats:italic>\n                    ~\n                    <jats:italic>B*08:01:01<\/jats:italic>\n                    ~\n                    <jats:italic>C*07:01:01<\/jats:italic>\n                    ~\n                    <jats:italic>DRB1*03:01:01<\/jats:italic>\n                    , which is typical of European descents. These results reflect a predominantly European genetic contribution, with additional African and Native American influences. These data extend understanding of genetic diversity about the Brazilian HLA system and provide information to characterise this population's HLA profile.\n                  <\/jats:p>","DOI":"10.1111\/tan.70948","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:16:44Z","timestamp":1790651804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Resolution\n                    <scp>HLA<\/scp>\n                    Allele and Haplotype Frequencies in a Southern Brazilian Population"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-4528","authenticated-orcid":false,"given":"Ana Paula Sokolowski","family":"de Lima","sequence":"first","affiliation":[{"name":"Biosciences and Physiopathology Program State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-4200","authenticated-orcid":false,"given":"Matheus","family":"Braga","sequence":"additional","affiliation":[{"name":"Biosciences and Physiopathology Program State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9602-7234","authenticated-orcid":false,"given":"Kayo Thiago Ribeiro","family":"Perroni","sequence":"additional","affiliation":[{"name":"Biosciences and Physiopathology Program State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3313-5458","authenticated-orcid":false,"given":"Julyane","family":"Schavaren","sequence":"additional","affiliation":[{"name":"Biosciences and Physiopathology Program State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 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