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To examine the genetic architecture of CeD in the admixed South Brazilian population, we sequenced the HLA alleles to high resolution and genotyped 16 non\u2010HLA polymorphisms, previously identified through genome\u2010wide association studies of Europeans in 171 CeD diagnosed patients and 195 controls. Controls had no CeD diagnosis, no first\u2010degree affected relatives, and were negative for anti\u2010TTg autoantibodies. As expected, we observed a predominance of\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DQA1*05:01:01~DQB1*02:01:01<\/jats:italic>\n                    (DQ2.5) and\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DQA1*02:01:01~DQB1*02:02:01<\/jats:italic>\n                    (DQ2.2) haplotypes among patients (51.7% and 40.2%, respectively). The ancestral 8.1 haplotype of HLA Class I and II alleles presented the highest odds of developing CeD (OR\u2009=\u20096.54, pcorr\u2009=\u20090.000065). By contrast,\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DQA1*01:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DQB1*05:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DRB1*08:02:01<\/jats:italic>\n                    and\n                    <jats:italic>HLA<\/jats:italic>\n                    \u2010\n                    <jats:italic>DRB1*13:01:01<\/jats:italic>\n                    were more frequent among controls (OR &lt;\u20090.4, pcorr &lt;\u20090.01). In contrast to results obtained in populations of predominantly European origin, HLA\u2010DQ8 frequencies did not differ between patients and controls. Among non\u2010HLA loci,\n                    <jats:italic>rs6691768*G<\/jats:italic>\n                    (g.61326191G\u2009&gt;\u2009A) in\n                    <jats:italic>NFIA<\/jats:italic>\n                    was associated with protection (OR\u2009=\u20090.32, pcorr\u2009=\u20090.039) and\n                    <jats:italic>rs653178*C (<\/jats:italic>\n                    g.111569952C\u2009&gt;\u2009T\n                    <jats:italic>)<\/jats:italic>\n                    (OR\u2009=\u20091.49, pcorr\u2009=\u20090.042) in ATXN2 was associated with susceptibility. This is the first high\u2010resolution HLA genotyping study of CeD in Brazil, providing a comprehensive overview of genetic susceptibility in an admixed population and highlighting new potential modulatory variants beyond the classical HLA loci.\n                  <\/jats:p>","DOI":"10.1111\/tan.70972","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:09:33Z","timestamp":1790410173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetics of Celiac Disease in Southern Brazil: High\u2010Resolution\n                    <scp>HLA<\/scp>\n                    Haplotypes and Non\u2010\n                    <scp>HLA<\/scp>\n                    Polymorphisms"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-3909","authenticated-orcid":false,"given":"Fernanda Vit\u00f3rio","family":"da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Human Molecular Genetics (LGMH), Department of Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"},{"name":"Postgraduation Program in Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-2417","authenticated-orcid":false,"given":"Val\u00e9ria Bumiller\u2010Bini","family":"Hoch","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics (LGMH), Department of Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"},{"name":"Postgraduation Program in Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-242X","authenticated-orcid":false,"given":"Eduardo Delabio","family":"Auer","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics (LGMH), Department of Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"},{"name":"Postgraduation Program in Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-5719","authenticated-orcid":false,"given":"Priscila Ianzen","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics (LGMH), Department of Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"},{"name":"Postgraduation Program in Internal Medicine Federal University of Paran\u00e1 (UFPR), Centro de Ci\u00eancias da Sa\u00fade, Curitiba  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2389-9699","authenticated-orcid":false,"given":"Noah","family":"Cline","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Colorado  Austin Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Caroline","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics (LGMH), Department of Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"},{"name":"Postgraduation Program in Genetics Federal University of Paran\u00e1 (UFPR), Centro Polit\u00e9cnico, Jardim das Am\u00e9ricas, Curitiba  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Elisabeth","family":"Hundt","sequence":"additional","affiliation":[{"name":"Luebeck Institute of Experimental Dermatology University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-4196","authenticated-orcid":false,"given":"Michael","family":"Wittig","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology (IKMB), Christian\u2010Albrechts\u2010University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology (IKMB), Christian\u2010Albrechts\u2010University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-7703","authenticated-orcid":false,"given":"Paul 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