{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:56:27Z","timestamp":1790531787970,"version":"4.1.0"},"reference-count":48,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Andaluc\u00eda-FEDER","award":["P09-AGR-4671"],"award-info":[{"award-number":["P09-AGR-4671"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transbound Emerg Dis"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1111\/tbed.12406","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T08:31:10Z","timestamp":1440491470000},"page":"574-584","source":"Crossref","is-referenced-by-count":6,"title":["Immunopathologic Changes in the Thymus of Calves Pre-infected with BVDV and Challenged with BHV-1"],"prefix":"10.1155","volume":"64","author":[{"given":"F.","family":"Romero-Palomo","sequence":"first","affiliation":[{"name":"Department of Comparative Pathology; Veterinary Faculty; University of C\u00f3rdoba-Agrifood Campus of International Excellence (ceiA3); C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Risalde","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology; Veterinary Faculty; University of C\u00f3rdoba-Agrifood Campus of International Excellence (ceiA3); C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"G\u00f3mez-Villamandos","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology; Veterinary Faculty; University of C\u00f3rdoba-Agrifood Campus of International Excellence (ceiA3); C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"10.1111\/tbed.12406-BIB0001|tbed12406-cit-0001","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/eji.201141889","article-title":"Affinity maturation of antibodies requires integrity of the adult thymus","volume":"42","author":"AbuAttieh","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1111\/tbed.12406-BIB0002|tbed12406-cit-0002","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0167-5699(97)01090-6","article-title":"Thymic dendritic cells","volume":"18","author":"Ardavin","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1111\/tbed.12406-BIB0003|tbed12406-cit-0003","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01652176.2013.799301","article-title":"Bovine herpesvirus-1 (BHV-1) - a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis","volume":"33","author":"Biswas","year":"2013","journal-title":"Vet. Q"},{"key":"10.1111\/tbed.12406-BIB0004|tbed12406-cit-0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-1135(98)00249-1","article-title":"Distribution of bovine virus diarrhoea virus in tissues and white blood cells of cattle during acute infection","volume":"64","author":"Bruschke","year":"1998","journal-title":"Vet. Microbiol."},{"key":"10.1111\/tbed.12406-BIB0005|tbed12406-cit-0005","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1128\/JVI.63.4.1525-1530.1989","article-title":"Inhibition of T-lymphocyte mitogenic responses and effects on cell functions by bovine herpesvirus 1","volume":"63","author":"Carter","year":"1989","journal-title":"J. Virol."},{"key":"10.1111\/tbed.12406-BIB0006|tbed12406-cit-0006","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1286-4579(99)00255-5","article-title":"TGF-beta1: immunosuppressant and viability factor for T lymphocytes","volume":"1","author":"Cerwenka","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1111\/tbed.12406-BIB0007|tbed12406-cit-0007","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/1521-4141(200103)31:3<802::AID-IMMU802>3.0.CO;2-P","article-title":"Thymic export in aged sheep: a continuous role for the thymus throughout pre- and postnatal life","volume":"31","author":"Cunningham","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1111\/tbed.12406-BIB0008|tbed12406-cit-0008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetimm.2014.03.018","article-title":"Changes observed in the thymus and lymph nodes 14\u00a0days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves","volume":"160","author":"Falkenberg","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1111\/tbed.12406-BIB0009|tbed12406-cit-0009","first-page":"181","article-title":"Bovine viral diarrhea virus (BVDV) 1b: predominant BVDV subtype in calves with respiratory disease","volume":"66","author":"Fulton","year":"2002","journal-title":"Can. J. Vet. Res."},{"key":"10.1111\/tbed.12406-BIB0010|tbed12406-cit-0010","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vetimm.2010.07.009","article-title":"Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry","volume":"138","author":"Gerner","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1111\/tbed.12406-BIB0011|tbed12406-cit-0011","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1099\/vir.0.18964-0","article-title":"Differential effects of bovine viral diarrhoea virus on monocytes and dendritic cells","volume":"84","author":"Glew","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1111\/tbed.12406-BIB0012|tbed12406-cit-0012","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4049\/jimmunol.1303398","article-title":"Bovine gammadelta T cells are a major regulatory T cell subset","volume":"193","author":"Guzman","year":"2014","journal-title":"J. Immunol."},{"key":"10.1111\/tbed.12406-BIB0013|tbed12406-cit-0013","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0167-5699(91)90109-7","article-title":"Prominence of gamma delta T cells in the ruminant immune system","volume":"12","author":"Hein","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1111\/tbed.12406-BIB0014|tbed12406-cit-0014","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1051\/vetres:2008044","article-title":"Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex\u00a0vivo","volume":"40","author":"Hoek","year":"2009","journal-title":"Vet. Res."},{"key":"10.1111\/tbed.12406-BIB0015|tbed12406-cit-0015","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1111\/tbed.12406-BIB0016|tbed12406-cit-0016","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0165-2427(92)90052-R","article-title":"Immunity to bovine virus diarrhoea virus in calves: the role of different T-cell subpopulations analysed by specific depletion in\u00a0vivo with monoclonal antibodies","volume":"32","author":"Howard","year":"1992","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1111\/tbed.12406-BIB0017|tbed12406-cit-0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0165-2427(93)90166-2","article-title":"Comparison of CD1 monoclonal antibodies on bovine cells and tissues","volume":"39","author":"Howard","year":"1993","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1111\/tbed.12406-BIB0018|tbed12406-cit-0018","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-7613(00)80056-4","article-title":"Generation of functional thymocytes in the human adult","volume":"10","author":"Jamieson","year":"1999","journal-title":"Immunity"},{"key":"10.1111\/tbed.12406-BIB0019|tbed12406-cit-0019","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cvfa.2010.04.007","article-title":"Bovine herpesvirus type 1 (BHV-1) is an important cofactor in the bovine respiratory disease complex","volume":"26","author":"Jones","year":"2010","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1111\/tbed.12406-BIB0020|tbed12406-cit-0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1111\/tbed.12406-BIB0021|tbed12406-cit-0021","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/104063870301500303","article-title":"Distribution of viral antigen and development of lesions after experimental infection of calves with a BVDV 2 strain of low virulence","volume":"15","author":"Liebler-Tenorio","year":"2003","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1111\/tbed.12406-BIB0022|tbed12406-cit-0022","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ni.1607","article-title":"A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells","volume":"9","author":"Liu","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1111\/tbed.12406-BIB0023|tbed12406-cit-0023","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.rvsc.2013.02.018","article-title":"Effect of infection with BHV-1 on peripheral blood leukocytes and lymphocyte subpopulations in calves with subclinical BVD","volume":"95","author":"Molina","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1111\/tbed.12406-BIB0024|tbed12406-cit-0024","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/tbed.12002","article-title":"Cell-mediated immune response during experimental acute infection with bovine viral diarrhoea virus: evaluation of blood parameters","volume":"61","author":"Molina","year":"2014","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1111\/tbed.12406-BIB0025|tbed12406-cit-0025","volume-title":"Janeway's Immunobiology","author":"Murphy","year":"2012","edition":"8"},{"key":"10.1111\/tbed.12406-BIB0026|tbed12406-cit-0026","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S1466252309990028","article-title":"Bovine herpes virus infections in cattle","volume":"10","author":"Nandi","year":"2009","journal-title":"Anim. Health Res. Rev."},{"key":"10.1111\/tbed.12406-BIB0027|tbed12406-cit-0027","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.biologicals.2012.07.002","article-title":"Molecular biology of bovine viral diarrhea virus","volume":"41","author":"Neill","year":"2013","journal-title":"Biologicals"},{"key":"10.1111\/tbed.12406-BIB0028|tbed12406-cit-0028","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.immuni.2010.04.012","article-title":"Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development","volume":"32","author":"Ouyang","year":"2010","journal-title":"Immunity"},{"key":"10.1111\/tbed.12406-BIB0029|tbed12406-cit-0029","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0192623311430693","article-title":"Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression","volume":"40","author":"Peterson","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1111\/tbed.12406-BIB0030|tbed12406-cit-0030","doi-asserted-by":"crossref","first-page":"19869","DOI":"10.1073\/pnas.0810268105","article-title":"Dendritic cells in the thymus contribute to T-regulatory cell induction","volume":"105","author":"Proietto","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/tbed.12406-BIB0031|tbed12406-cit-0031","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/0300985811414031","article-title":"Virus distribution and role of thymic\u00a0macrophages during experimental infection with noncytopathogenic bovine viral diarrhea virus type 1","volume":"49","author":"Raya","year":"2012","journal-title":"Vet. Pathol."},{"key":"10.1111\/tbed.12406-BIB0032|tbed12406-cit-0032","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/0300985814535610","article-title":"Role of thymic epithelial cells in lymphoid depletion after experimental infection with the noncytopathogenic BVDV1 strain 7443","volume":"52","author":"Raya","year":"2015","journal-title":"Vet. Pathol."},{"key":"10.1111\/tbed.12406-BIB0033|tbed12406-cit-0033","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1128\/JVI.73.6.4840-4846.1999","article-title":"Susceptibility of bovine antigen-presenting cells to infection by bovine herpesvirus 1 and in\u00a0vitro presentation to T cells: two independent events","volume":"73","author":"Renjifo","year":"1999","journal-title":"J. Virol."},{"key":"10.1111\/tbed.12406-BIB0034|tbed12406-cit-0034","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0092-8674(01)00454-8","article-title":"The host-pathogen interaction: new themes from dendritic cell biology","volume":"106","author":"Rescigno","year":"2001","journal-title":"Cell"},{"key":"10.1111\/tbed.12406-BIB0035|tbed12406-cit-0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cvfa.2009.10.007","article-title":"Bovine viral diarrhea virus: global status","volume":"26","author":"Ridpath","year":"2010a","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1111\/tbed.12406-BIB0036|tbed12406-cit-0036","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cvfa.2010.04.003","article-title":"The contribution of infections with bovine viral diarrhea viruses to bovine respiratory disease","volume":"26","author":"Ridpath","year":"2010b","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1111\/tbed.12406-BIB0037|tbed12406-cit-0037","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.vetimm.2011.07.022","article-title":"Response of proinflammatory and anti-inflammatory cytokines in calves with subclinical bovine viral diarrhea challenged with bovine herpesvirus-1","volume":"144","author":"Risalde","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1111\/tbed.12406-BIB0038|tbed12406-cit-0038","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1297-9716-44-20","article-title":"Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1","volume":"44","author":"Risalde","year":"2013a","journal-title":"Vet. Res."},{"key":"10.1111\/tbed.12406-BIB0039|tbed12406-cit-0039","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2460\/ajvr.74.4.598","article-title":"Comparison of pathological changes and viral antigen distribution in tissues of calves with and without preexisting bovine viral diarrhea virus infection following challenge with bovine herpesvirus-1","volume":"74","author":"Risalde","year":"2013b","journal-title":"Am. J. Vet. Res."},{"key":"10.1111\/tbed.12406-BIB0040|tbed12406-cit-0040","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/0300985814551579","article-title":"Effects of preinfection with bovine viral diarrhea virus on immune cells from the lungs of calves inoculated with bovine herpesvirus 1.1","volume":"52","author":"Risalde","year":"2015","journal-title":"Vet. Pathol."},{"key":"10.1111\/tbed.12406-BIB0041|tbed12406-cit-0041","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/0300985813482951","article-title":"Immunohistochemical detection of dendritic cell markers in cattle","volume":"50","author":"Romero-Palomo","year":"2013","journal-title":"Vet. Pathol."},{"key":"10.1111\/tbed.12406-BIB0042|tbed12406-cit-0042","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.vetmic.2015.02.018","article-title":"Characterization of thymus atrophy in calves with subclinical BVD challenged with BHV-1","volume":"177","author":"Romero-Palomo","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1111\/tbed.12406-BIB0043|tbed12406-cit-0043","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1074-7613(00)80615-9","article-title":"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment","volume":"9","author":"Saint-Vis","year":"1998","journal-title":"Immunity"},{"key":"10.1111\/tbed.12406-BIB0044|tbed12406-cit-0044","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/intimm\/dxp095","article-title":"Regulatory T cells: how do they suppress immune responses?","volume":"21","author":"Sakaguchi","year":"2009","journal-title":"Int. Immunol."},{"key":"10.1111\/tbed.12406-BIB0045|tbed12406-cit-0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.coi.2011.05.001","article-title":"Altered thymic activity in early life: how does it affect the immune system in young adults?","volume":"23","author":"Sauce","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1111\/tbed.12406-BIB0046|tbed12406-cit-0046","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1017\/S1466252307001326","article-title":"Immune evasion by pathogens of bovine respiratory disease complex","volume":"8","author":"Srikumaran","year":"2007","journal-title":"Anim. Health Res. Rev."},{"key":"10.1111\/tbed.12406-BIB0047|tbed12406-cit-0047","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1034\/j.1600-0463.2003.11107802.x","article-title":"Some interfaces of dendritic cell biology","volume":"111","author":"Steinman","year":"2003","journal-title":"APMIS"},{"key":"10.1111\/tbed.12406-BIB0048|tbed12406-cit-0048","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.bpj.2012.07.059","article-title":"On the role of CD8 T cells in the control of persistent infections","volume":"103","author":"Stromberg","year":"2012","journal-title":"Biophys. J."}],"container-title":["Transboundary and Emerging Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftbed.12406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftbed.12406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/tbed.12406\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T15:46:03Z","timestamp":1675957563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tbed.12406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1111\/tbed.12406","archive":["Portico"],"relation":{},"ISSN":["1865-1674"],"issn-type":[{"value":"1865-1674","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}