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In this study, we described that the H3N2 swine influenza (swH3N2) viruses currently circulating in pigs in Guangdong province carried six internal genes from 2009 pandemic H1N1 virus (pmd09), and their antigenicity was obviously different from that of current human H3N2 influenza viruses or recommended vaccine strains (A\/Guangdong\/1194\/2019, A\/Hong Kong\/4801\/2014). These swH3N2 viruses preferentially bonded to the human\u2010like receptors, and efficiently replicated in human, canine and swine cells. In addition, the virus replicated in turbinate and trachea of guinea pigs, and efficiently transmitted among guinea pigs, and virus shedding last for 6 days post\u2010infection (dpi). The virus replicated in the respiratory tract of pigs, effectively transmitted among pigs, and virus shedding last until 9 dpi. Taken together, these current swH3N2 viruses might have the zoonotic potential. Strengthening surveillance and monitoring the pathogenicity of such swH3N2 viruses are urgently needed.<\/jats:p>","DOI":"10.1111\/tbed.14190","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T06:12:03Z","timestamp":1623823923000},"page":"2052-2064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pathogenicity and transmissibility of current H3N2 swine influenza virus in Southern China: A zoonotic potential"],"prefix":"10.1155","volume":"69","author":[{"given":"Yanan","family":"Yu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou China"},{"name":"National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control  Guangzhou China"},{"name":"Guangdong Laboratory for Lingnan Modern Agriculture  Guangzhou China"},{"name":"Key Laboratory of Zoonosis Control and Prevention of 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