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To improve our understanding of this dynamic, we employed multi\u2010locus genotyping to conduct a cross\u2010sectional study of the potential for zoonotic transmission of the protozoan parasite <jats:italic>Giardia duodenalis<\/jats:italic> among humans, household associated livestock and dogs, and black and gold howler monkeys (<jats:italic>Alouatta caraya<\/jats:italic>) in the Corrientes Province of Argentina. We found <jats:italic>Giardia<\/jats:italic> prevalence to be highest in howler monkeys (90.3% (47\/52)), followed by humans (61.1% (22\/36)), dogs (44.4% (16\/36)), and cattle (41.9% (18\/43)). We further established that howler monkeys exclusively harbored strains of assemblage B (100%) while humans were infected with either assemblage A (13.3%) or B (80%) or A and B (6.7%), and cattle and dogs were infected with either assemblage A (cattle, 94.1%; dogs, 80%)), A and C (10%), or their host\u2010adapted assemblage (cattle, 5.9%; dogs, 10%). Our finding of <jats:italic>G. duodenalis<\/jats:italic> in both humans and domesticated animals (assemblage A) and humans and wild primates (assemblage B) suggests that cross\u2010species transmission of multiple assemblages of <jats:italic>G. duodenalis<\/jats:italic> may occur in rural complexes such as northern Argentina where people, domesticated animals, and wildlife overlap. We further highlight the need to investigate the implications of these results for human health, the economics of livestock production, and wildlife conservation in this and similar systems.<\/jats:p>","DOI":"10.1111\/tbed.14220","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T19:49:55Z","timestamp":1625514595000},"page":"2209-2218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Molecular characterization of <i>Giardia duodenalis<\/i> and evidence for cross\u2010species transmission in Northern Argentina"],"prefix":"10.1155","volume":"69","author":[{"given":"Sahana","family":"Kuthyar","sequence":"first","affiliation":[{"name":"Department of Environmental Sciences Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences Emory University  Atlanta Georgia USA"},{"name":"Estaci\u00f3n Biol\u00f3gica Corrientes, Museo Argentino de Ciencias Naturales \u201cBernardino Rivadavia\u201d (MACN\u2010CONICET)  Corrientes Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Seabolt","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"},{"name":"CFD Research Corporation  Huntsville Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Roellig","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-7248","authenticated-orcid":false,"given":"Thomas R.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences Emory University  Atlanta Georgia USA"},{"name":"Program in Population Biology, Ecology, and Evolutionary Biology and Department of Environmental Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02305\u201009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.06.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010007\u20100623\u20107"},{"key":"e_1_2_8_5_1","first-page":"227","article-title":"Intestinal parasitism in San Cayetano, Corrientes, Argentina","volume":"30","author":"Borda C. 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