{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:23:38Z","timestamp":1772799818796,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transbounding Emerging Dis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The SARS\u2010CoV\u20102 virus was detected for the first time in December 2019 in Wuhan, China. Currently, this virus has spread around the world, and new variants have emerged. This new pandemic virus provoked the rapid development of diagnostic tools, therapies and vaccines to control this new disease called COVID\u201019. Antibody detection by ELISA has been broadly used to recognize the number of persons infected with this virus or to evaluate the response of vaccinated individuals. As the pandemic spread, new questions arose, such as the prevalence of antibodies after natural infection and the response induced by the different vaccines. In Mexico, as in other countries, mRNA and viral\u2010vectored vaccines have been widely used among the population. In this work, we developed an indirect ELISA test to evaluate S1 antibodies in convalescent and vaccinated individuals. By using this test, we showed that IgG antibodies against the S1 protein of SARS\u2010CoV\u20102 were detected up to 42\u00a0weeks after the onset of the symptoms, in contrast to IgA and IgM, which decreased 14\u00a0weeks after the onset of symptoms. The evaluation of the antibody response in individuals vaccinated with Pfizer\u2010BioNTech and CanSinoBio vaccines showed no differences 2 weeks after vaccination. However, after completing the two doses of Pfizer\u2010BioNTech and the one dose of CanSinoBio, a significantly higher response of IgG antibodies was observed in persons vaccinated with Pfizer\u2010BioNTech than in those vaccinated with CanSinoBio. In conclusion, these results confirm that after natural infection with SARS\u2010CoV\u20102, it is possible to detect antibodies for up to 10 months. Additionally, our results showed that one dose of the CanSinoBio vaccine induces a lower response of IgG antibodies than that induced by the complete scheme of the Pfizer\u2010BioNTech vaccine.<\/jats:p>","DOI":"10.1111\/tbed.14344","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T03:17:49Z","timestamp":1634613469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of IgG, IgA and IgM antibodies against SARS\u2010CoV\u20102 spike protein S1 in convalescent and vaccinated patients with the Pfizer\u2010BioNTech and CanSinoBio vaccines"],"prefix":"10.1155","volume":"69","author":[{"given":"Edgar A.","family":"Melgoza\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Hinojosa\u2010Trujillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Res\u00e9ndiz\u2010Sandoval","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-4569","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Mata\u2010Haro","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda e Inmunolog\u00eda Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C  Hermosillo 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A","family":"Arvizu\u2010Flores","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas Divisi\u00f3n de Ciencias de la Salud Universidad de Sonora  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-2107","authenticated-orcid":false,"given":"Olivia","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas Divisi\u00f3n de Ciencias de la Salud Universidad de Sonora  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Centro Estatal de la Transfusi\u00f3n Sangu\u00ednea Secretaria de Salud del Estado de Sonora  Hermosillo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Soto\u2010Gaxiola","sequence":"additional","affiliation":[{"name":"Hospital General del 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