{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:40:36Z","timestamp":1776922836788,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In allogeneic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>), reduced\u2010intensity conditioning (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>) is known for producing less regimen\u2010related toxicity. However, whether or not <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> reduces the risk for infection and infection\u2010related mortality (<jats:styled-content style=\"fixed-case\">IRM<\/jats:styled-content>) remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed infectious episodes and <jats:styled-content style=\"fixed-case\">IRM<\/jats:styled-content>s after allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>s by time period and by the intensity of the conditioning regimen (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> [<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>81] vs. myeloablative conditioning, <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> [<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>150]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of any kind of infection was lower in the <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> group through the entire period (72% vs. 87%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007). The onset of infections was deferred in the <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> group as compared with the <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.012). Bacteremia occurred less frequently in the <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> group through the entire period (5% vs. 14%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.044). However, the incidences of cytomegalovirus reactivation and disease, herpes zoster, virus\u2010associated hemorrhagic cystitis, and invasive fungal infection were not different between the two groups. Furthermore, there was no difference in relapse\u2010free survival and <jats:styled-content style=\"fixed-case\">IRM<\/jats:styled-content> between the two conditioning regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Careful monitoring and appropriate preventive\/therapeutic strategies for infectious complications, comparable to those for allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> recipients with <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>, should also be applied to those with <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>, especially after engraftment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12003","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T06:55:22Z","timestamp":1348469722000},"page":"49-59","source":"Crossref","is-referenced-by-count":36,"title":["Infectious complications following allogeneic stem cell transplantation: reduced\u2010intensity vs. myeloablative conditioning regimens"],"prefix":"10.1111","volume":"15","author":[{"given":"S.\u2010H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Konkuk University Chungju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Catholic Blood and Marrow Transplantation Center Seoul St. Mary\u2018s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010M.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010C.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine National Health Insurance Corporation Ilsan Hospital Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010S.","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Catholic Blood and Marrow Transplantation Center Seoul St. Mary\u2018s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010K.","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"Catholic Blood and Marrow Transplantation Center Seoul St. Mary\u2018s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine The Catholic University 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