{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:29Z","timestamp":1791308669306,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 39\u2010year\u2010old male patient who died of severe <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>) pneumonia 168\u00a0days after hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) for acute lymphoblastic leukemia. After suffering from <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010associated late\u2010onset hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) with long\u2010term sustained <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia, he died of rapidly progressive pneumonia. On autopsy, numerous viral intranuclear inclusions were seen in his lungs and bladder. An immunohistochemical examination of his lungs was positive for simian virus 40. Based on these pathological results and the high sustained <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viral load in his blood, we reached a diagnosis of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> pneumonia. Viral infection can occasionally become life threatening among <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients. It is widely known that <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> can cause late\u2010onset <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010associated pneumonia is rare. Because of its rapid progression and poor prognosis, it is difficult to make an antemortem diagnosis of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> pneumonia. A treatment strategy for <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> pneumonia also needs to be formulated. Similar to other viral pathogens, <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> can cause pneumonia and the clinician should therefore be aware of it in immunocompromised patients.<\/jats:p>","DOI":"10.1111\/tid.12011","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T06:55:41Z","timestamp":1348469741000},"source":"Crossref","is-referenced-by-count":30,"title":["Fatal <scp>BK<\/scp> virus pneumonia following stem cell transplantation"],"prefix":"10.1111","volume":"14","author":[{"given":"Y.","family":"Akazawa","sequence":"first","affiliation":[{"name":"Hematology Graduate School of Medicine, Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Terada","sequence":"additional","affiliation":[{"name":"Hematology Graduate School of Medicine, Osaka City University Osaka 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