{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:00:43Z","timestamp":1763017243347},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxoplasmosis is increasingly diagnosed after hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) and is associated with considerable morbidity and mortality. In the majority of cases, reactivation of latent disease secondary to impaired cellular and humoral immunity after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is believed to be the main pathogenetic mechanism. Hence, primary toxoplasmosis is rarely considered in the differential diagnosis of infections after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in a recipient who is seronegative for <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oxoplasma gondii<\/jats:italic> pre\u2010transplant. We herein report a seronegative patient with acute T\u2010cell lymphoblastic leukemia, who developed primary disseminated toxoplasmosis 5\u00a0months after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from a seronegative unrelated donor. A review of all reported cases of primary toxoplasmosis after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> revealed significantly increased morbidity and mortality. Patients with negative pre\u2010transplant <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oxoplasma<\/jats:italic> serology should therefore be considered at risk for toxoplasmosis after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Possible prevention and monitoring strategies for seronegative recipients are reviewed and discussed in detail.<\/jats:p>","DOI":"10.1111\/tid.12043","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T02:04:04Z","timestamp":1356141844000},"source":"Crossref","is-referenced-by-count":19,"title":["Disseminated toxoplasmosis after allogeneic stem cell transplantation in a seronegative recipient"],"prefix":"10.1111","volume":"15","author":[{"given":"M.","family":"Osthoff","sequence":"first","affiliation":[{"name":"Victorian Infectious Diseases Service Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Royal Melbourne Hospital Parkville Victoria 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