{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:01:10Z","timestamp":1763017270215},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:00:00Z","timestamp":1362528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The developments of peripheral blood stem cells in autologous hematopoietic stem cell transplantation (auto\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>), and of reduced\u2010intensity conditioning (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>) regimens in allogeneic <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> (allo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>), have considerably changed the transplant approach. Prolonged neutropenia combined with severe mucosal damage and organ dysfunction is no longer the rule in the early post\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> pancytopenic phase. Although strict isolation during pancytopenia was followed by most <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> units in the past, this may not be the current practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2008, a questionnaire was sent out to the 463 European Group for Blood and Marrow Transplantation centers, enquiring about their current environmental protection procedures; 89 (20%) returned the questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most centers housed auto\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> recipients in high\u2010efficiency particulate air (<jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content>)\u2010filtered rooms without (52%) or with laminar air flow (<jats:styled-content style=\"fixed-case\">LAF<\/jats:styled-content>) (29%) after total body irradiation (<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>), whereas <jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content>\u2010filtered rooms were used in 53% of auto\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> conditioned without <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>. During the initial pancytopenic phase after allo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>, patients were housed in <jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LAF<\/jats:styled-content> rooms in 50% and 42% of the centers, if a high\u2010dose myeloablative conditioning regimen or a <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> regimen was used, respectively. Surprisingly, 8\u201324% of the centers reported that no isolation procedures were used in patients colonized or infected with highly transmissible pathogens (i.e., <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lostridium difficile<\/jats:italic>, respiratory viruses, and varicella zoster virus).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, universal recommendations for infected or colonized patients may be poorly known or applied in many <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> units.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12064","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T17:38:31Z","timestamp":1362591511000},"page":"251-258","source":"Crossref","is-referenced-by-count":29,"title":["Environmental prevention of infection in stem cell transplant recipients: a survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation"],"prefix":"10.1111","volume":"15","author":[{"given":"Y.","family":"Hicheri","sequence":"first","affiliation":[{"name":"Haematology Department Henri Mondor Teaching Hospital Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) and Paris Est\u2010Cr\u00e9teil University Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Einsele","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Martino","sequence":"additional","affiliation":[{"name":"Haematology Department Sant Pau Hospital Universitat Aut\u00f3noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Paediatric Haematology Oncology Policlinico G.B. 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