{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:30Z","timestamp":1791308670315,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The use of real\u2010time polymerase chain reaction testing in the investigation of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>)\u2010associated disease has been widely studied in renal transplant recipients; however, far less research has been done in this area with respect to the plasma <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viral load dynamics of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) in hematopoietic stem cell transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to examine the <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viral load dynamics in plasma samples collected from patients post transplant who had laboratory\u2010confirmed <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who developed <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia were compared with patients who did not develop viremia, and a statistical comparison of risk factors for viremia was performed. Seventeen patients were included in this study. Urine samples from the day of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> diagnosis were available in 13 of the 17 cases. In total, 154 archived plasma samples from around the time of the <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> event were also included in the study from these 17 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time from transplantation to the onset of detectable viremia was 68\u00a0days. The median viral load in the 13 urine samples was 1.8\u00a0\u00d7\u00a010<jats:sup>8<\/jats:sup> copies\/mL, which was significantly higher than the median viral load in the 38 positive plasma samples of 6.6\u00a0\u00d7\u00a010<jats:sup>2<\/jats:sup> copies\/mL (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney test, <jats:italic>U<\/jats:italic>\u00a0=\u00a016, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lymphocyte count on the day of the positive <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> test was significantly lower in patients with <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia than in patients with no viremia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and also the white cell and platelet counts were lower on the day of the first positive <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> test. Although there is not inter\u2010patient consistency as regards correlation between urinary <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viral loads and severity of clinical <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, in individual patients the decline in viral load in plasma did correlate with clinical recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12066","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T13:02:44Z","timestamp":1362747764000},"page":"276-282","source":"Crossref","is-referenced-by-count":17,"title":["<scp>BK<\/scp> virus (<scp>BKV<\/scp>) plasma dynamics in patients with <scp>BKV<\/scp>\u2010associated hemorrhagic cystitis following allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"15","author":[{"given":"R.J.","family":"Drew","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology St James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"N\u00ed Laoi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology St James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Conneally","sequence":"additional","affiliation":[{"name":"Department of Haematology St James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology St James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91776-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90608-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150405"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01346.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01318.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313888"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP63VDFCKCRUUL"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.08.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00040-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20566"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/324425"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(82)90633-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-30-36"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4988"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/426140"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:06:28Z","timestamp":1700629588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,8]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/tid.12066"],"URL":"https:\/\/doi.org\/10.1111\/tid.12066","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,8]]}}}