{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:07:56Z","timestamp":1761919676419},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biliary complications (<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s) and recurrent hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection are among the major causes of morbidity and graft loss following liver transplantation. The influence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s has not been definitely clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We performed a retrospective cohort study to analyze risk factors and outcome of post orthotopic liver transplantation (<jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s in 352 liver transplant recipients over 12\u00a0years in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>unich, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany (<jats:italic>n<\/jats:italic>\u00a0=\u00a084 with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>; living donor and re\u2010<jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content> were excluded). <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s diagnosed with imaging techniques and abnormal liver enzyme pattern, requiring an intervention, were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multivariate analysis, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> serostatus and a high pre\u2010and post\u2010surgery <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> serum load were independent risk factors for anastomotic strictures. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> positivity and <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s alone did not alter graft loss. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive patients with <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s, however, had a significantly worse graft outcome (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Non\u2010anastomotic strictures, bile leaks, and the number of interventions needed to treat bile leaks led to worse graft outcome in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> positivity and a high <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> serum load were risk factors for anastomotic strictures. <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> had an additive effect on graft loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12069","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T18:43:07Z","timestamp":1363372987000},"page":"306-313","source":"Crossref","is-referenced-by-count":11,"title":["Influence of hepatitis C virus infection and high virus serum load on biliary complications in liver 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