{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:04:38Z","timestamp":1755695078951},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) disease is one of the major infectious complications that can occur after allogeneic hematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Many reports have shown visceral <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection, a special type of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> disease, to be rare. However, few studies so far have included a large number of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Visceral <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection was found in 20 (0.8%) of 2411 patients who underwent allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> at our hospitals. Seventeen (85%) patients were taking immunosuppressive agents at the time of presentation with zoster. The presenting symptom was abdominal pain in 16 patients (80%), unconsciousness in 3 patients (15%), and no symptoms in 1 patient. The mean time interval from allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> to symptomatic visceral <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection was 273\u00a0days (103\u2013800\u00a0days). The eruptions appeared within 3\u00a0days (0\u201313) after the first symptoms. Treatment with intravenous acyclovir was initiated before the appearance of eruptions in 3 of 18 patients (all 3 survived) with vesicular eruptions, the same day in 12 patients (11 survived, 1 died), and after the appearance in 3 patients (1 survived, 2 died). The overall mortality was 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, these data confirm that the incidence of visceral <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection is infrequent, but this disease is serious. When patients being treated with immunosuppressive agents demonstrate abdominal pain or unconsciousness, the possibility of visceral <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection should be considered as well as earlier therapeutic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12073","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T03:26:52Z","timestamp":1364873212000},"page":"314-318","source":"Crossref","is-referenced-by-count":29,"title":["Visceral varicella zoster virus infection after allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"15","author":[{"given":"N.","family":"Doki","sequence":"first","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"},{"name":"Leukemia Research Center Saiseikai Maebashi Hospital Maebashi, Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Leukemia Research Center Saiseikai Maebashi Hospital Maebashi, Gunma Japan"},{"name":"Division of Hematology Tokyo Metropolitan Ohtsuka Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kudo","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wake","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo 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Hematology Department of Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Institute of Medical Science University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Kanto Study Group for Cell 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