{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:46:45Z","timestamp":1791398805385,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Respiratory viruses are an important yet underestimated cause of infectious morbidity and mortality in immunocompromised children and adolescents. Here, we report the occurrence of fatal lower respiratory tract disease associated with human metapneumovirus (<jats:styled-content style=\"fixed-case\">HMPV<\/jats:styled-content>) infection in a 10\u2010year\u2010old girl with chronic graft\u2010versus\u2010host disease following allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) for secondary chronic myeloid leukemia. Symptoms occurred 8\u00a0months after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> while on immunosuppression with 0.2\u00a0mg\/kg\/day of prednisone, and presented as dry cough, bilateral pneumonitis, and progressive respiratory distress. Non\u2010invasive and invasive microbiological investigations revealed <jats:styled-content style=\"fixed-case\">HMPV<\/jats:styled-content> type B as the sole pathogen. Histopathological findings showed interstitial and intra\u2010alveolar pneumonitis with profound alveolar cell damage. The patient was treated with intravenous and oral ribavirin and polyvalent immunoglobulins, but ultimately died from respiratory failure. The case reflects the potentially fatal impact of infections by respiratory viruses in immunocompromised patients and the need for effective approaches to their prevention and treatment.<\/jats:p>","DOI":"10.1111\/tid.12074","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T01:43:17Z","timestamp":1364866997000},"source":"Crossref","is-referenced-by-count":39,"title":["Fatal human metapneumovirus infection following allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"15","author":[{"given":"C.","family":"Dokos","sequence":"first","affiliation":[{"name":"Infectious Disease Research Program Center for Bone Marrow Transplantation, University Children's Hospital M\u00fcnster, M\u00fcnster, Germany and Department of Pediatric Hematology\/Oncology University Children's Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Masjosthusmann","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics University Children's Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rellensmann","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics University Children's Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics University Children's Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schuler\u2010L\u00fcttmann","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University Hospital M\u00fcnster, University Medical Center M\u00fcnster 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