{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:09:00Z","timestamp":1783152540798,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T00:00:00Z","timestamp":1365897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Progressive multifocal leukoencephalopathy (<jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content>) is associated with <jats:styled-content style=\"fixed-case\">JC<\/jats:styled-content> polyomavirus (<jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>) infection of central nervous system oligodendrocytes resulting in demyelinization and progressive focal neurologic deficits. Reactivation of dormant <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content> occurs in the setting of immunosuppression, most commonly in patients with human immunodeficiency virus (HIV)\/acquired immunodeficiency syndrome (AIDS) or hematological malignancies. <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> has also been reported in solid organ transplant recipients. We report the case of a 61\u2010year\u2010old man after bilateral lung transplantation for chronic hypersensitivity pneumonitis who presented with leg weakness, cognitive decline, and expressive aphasia at 5\u00a0months post transplantation. Magnetic resonance imaging and brain biopsy were consistent with <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content>. Treatment attempt with cytarabine was unsuccessful, and immunomodulation resulted in recurrent grade A3 rejection. The difficulty of managing <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> in lung transplant patients is highlighted by the lack of directed therapy and risk of graft rejection or failure with attempts at decreasing immunosuppression.<\/jats:p>","DOI":"10.1111\/tid.12080","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T03:29:05Z","timestamp":1365996545000},"source":"Crossref","is-referenced-by-count":7,"title":["Leg weakness in a lung transplant patient"],"prefix":"10.1111","volume":"15","author":[{"given":"T.","family":"Moua","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Rizza","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00804-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2000.020106.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.12.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22408"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.03.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21486"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00147-004-0779-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000150537"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200406000-00019"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.78.s2.09"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.1.8451420"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24966"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/427698"},{"issue":"5","key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1128\/jcm.34.5.1343-1346.1996","article-title":"Improved detection of JC virus DNA in cerebrospinal fluid for diagnosis of AIDS\u2010related progressive multifocal leukoencephalopathy","volume":"34","author":"de Luca A","year":"1996","journal-title":"J Clin Microbiol"},{"issue":"12","key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1128\/jcm.34.12.2929-2932.1996","article-title":"Analysis of PCR as a tool for detection of JC virus DNA in cerebrospinal fluid for diagnosis of progressive multifocal leukoencephalopathy","volume":"34","author":"Hammarin AL","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280152537292"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805073381903"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007794"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:06:59Z","timestamp":1700629619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,14]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/tid.12080"],"URL":"https:\/\/doi.org\/10.1111\/tid.12080","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,14]]}}}