{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:43:41Z","timestamp":1771631021626,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) is a common infectious disease after kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>). The incidence of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> may increase during cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) preemptive therapy. We therefore evaluated the incidence, risk factors, and clinical outcomes of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>, according to the type of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively established a cohort of <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients who underwent transplantation from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2008 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2010. Patients were categorized into 3 groups according to <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis regimen: Group A (preemptive therapy), Group B (universal prophylaxis &lt;3\u00a0months), and Group C (universal prophylaxis &gt;3\u00a0months). The incidence rate of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> was compared in each group, and risk factors for <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> was 46.6 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 31.4\u201366.5) per 1000 person\u2010years. The incidence rate was higher in Group A than in Group C (80.0 vs. 13.0 per 1000 person\u2010years; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Median onset time of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> was shorter in Group A than in Group B (0.9 vs. 9.9\u00a0months; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and Group C (0.9 vs. 14.8\u00a0months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Post\u2010herpetic neuralgia occurred in 7 patients (23%). No visceral involvement or death was related to <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. By multivariate analysis, only female gender (corrected relative risk 1.59; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.09\u20132.00) was independently associated with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the setting of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> preemptive therapy, a differentiated varicella zoster virus\u2010specific prophylaxis might be necessary for patients with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12091","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T03:49:50Z","timestamp":1368676190000},"page":"416-423","source":"Crossref","is-referenced-by-count":22,"title":["Increased incidence of herpes zoster in the setting of cytomegalovirus preemptive therapy after kidney transplantation"],"prefix":"10.1111","volume":"15","author":[{"given":"G.B.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Republic of 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010O.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.12_Suppl_8.S41"},{"key":"e_1_2_6_3_1","volume-title":"Transpant Infections","author":"Bowden RA","year":"2010"},{"key":"e_1_2_6_4_1","volume-title":"Prevention and Treatment of Cancer\u2010Related Infections, version 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