{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:26:24Z","timestamp":1773393984953,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to present a fatal case of fulminant hepatitis B (<jats:styled-content style=\"fixed-case\">FHB<\/jats:styled-content>) that developed in a renal transplant recipient, immunized against hepatitis B, 1\u00a0year post transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Polymerase chain reaction amplification and full genome sequencing were performed to investigate whether specific mutations were associated with hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) transmission and <jats:styled-content style=\"fixed-case\">FHB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Molecular analysis revealed multiple mutations in various open reading frames of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>, the most important being the G145R escape mutation and a frameshift mutation\u2013insertion (1838insA) within the pre\u2010C\/C reading frame.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results highlight the possibility of developing <jats:styled-content style=\"fixed-case\">FHB<\/jats:styled-content>, despite previous immunization against <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> or administration of hyperimmune gammaglobulin, because of the selection of escape virus mutants. The current literature and guidelines regarding renal transplantation from hepatitis B surface antigen (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg)\u2010positive to <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010negative patients were also reviewed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12094","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T07:22:54Z","timestamp":1371453774000},"page":"393-399","source":"Crossref","is-referenced-by-count":20,"title":["Renal transplantation from hepatitis B surface antigen (<scp>HB<\/scp>sAg)\u2010positive donors to <scp>HB<\/scp>sAg\u2010negative recipients: a case of post\u2010transplant fulminant hepatitis associated with an extensively mutated hepatitis B virus strain and review of the current literature"],"prefix":"10.1111","volume":"15","author":[{"given":"E.","family":"Magiorkinis","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Paraskevis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.D.","family":"Pavlopoulou","sequence":"additional","affiliation":[{"name":"Pediatric Research Laboratory Faculty of Nursing University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kantzanou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Haida","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hatzakis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.N.","family":"Boletis","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Unit \u201cLaikon\u201d Hospital Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i1.82"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242405"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90286-T"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78441-5"},{"issue":"8","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1128\/JCM.38.8.2975-2981.2000","article-title":"Molecular epidemiology of an outbreak of fulminant hepatitis B","volume":"38","author":"Petrosillo N","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1288-1294.2006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1180-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90713-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.3.1298-1303.1990"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242404"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00325-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21249"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1785-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21167"},{"key":"e_1_2_5_16_1","volume-title":"Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4.0 beta","author":"Swofford DL","year":"2002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00588.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-4-199502150-00001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2197-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210835"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-4-11"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800882"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250633"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.09.056"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.06.020"},{"issue":"4","key":"e_1_2_5_27_1","first-page":"530","article-title":"Gene heterogeneity of hepatitis B virus isolates from patients with severe hepatitis B","volume":"4","author":"Wu W","year":"2005","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1109782"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01291.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1123989"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.3.1651-1659.1994"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.10.094"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2489"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.009"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01329.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN107565"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31824e3db4"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2003.03303.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80239-5"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240203"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280530"},{"issue":"2","key":"e_1_2_5_42_1","first-page":"S257","article-title":"Failure of hepatitis B surface antibody to protect acute fulminating hepatitis in a renal transplant recipient","volume":"89","author":"Sobhonslidsuk A","year":"2006","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02719.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.499"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00678.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02093794"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.12.002"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1448"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5761"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26516"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80212-2"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1997-5"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-3-110"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12094","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:15:11Z","timestamp":1696198511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,17]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/tid.12094"],"URL":"https:\/\/doi.org\/10.1111\/tid.12094","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,17]]}}}