{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:14:08Z","timestamp":1771265648006,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Vaginal chronic graft\u2010versus\u2010host disease (cGVHD<\/jats:styled-content>) is a common complication of stem cell transplantation. Human papillomavirus (HPV<\/jats:styled-content>) disease can reactivate after transplantation, presumably because of immune factors affecting systemic immunity, such as waning antibody titers, impaired T\u2010 and B\u2010lymphocyte responses, and the use of immunosuppressive therapies. However, a relationship between the use of local immunosuppressive agents and HPV<\/jats:styled-content> reactivation and spread has not been previously described, to our knowledge. A 30\u2010year\u2010old woman, 2\u00a0years post transplant receiving systemic cyclosporine for cGVHD<\/jats:styled-content>, was treated with vaginal dilators, topical corticosteroids, and estrogen for vaginal cGVHD<\/jats:styled-content>. Colposcopy and biopsy for abnormal cytology revealed condylomatous cervicitis. Over the next 4\u00a0months, while continuing dilator therapy, linear verrucous lesions developed in the vagina and vulva, and were successfully treated with laser therapy. Use of local immunosuppression and dilators for genital GVHD<\/jats:styled-content> can enhance spread of HPV<\/jats:styled-content> infection. Integration of HPV<\/jats:styled-content> screening and treatment into the care of women with genital cGVHD<\/jats:styled-content> and development of strategies to manage both conditions simultaneously are warranted.<\/jats:p>","DOI":"10.1111\/tid.12098","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T07:06:46Z","timestamp":1369724806000},"source":"Crossref","is-referenced-by-count":19,"title":["Human papillomavirus reactivation following treatment of genital graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"15","author":[{"given":"T.","family":"Sri","sequence":"first","affiliation":[{"name":"Epsom and St Helier University Hospitals NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Merideth","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA"},{"name":"Intramural Office of Rare Diseases Office of the Director National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Klepac","family":"Pulanic","sequence":"additional","affiliation":[{"name":"Community Health Center East Zagreb Croatia"},{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Childs","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.10.015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2011.10.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.07.005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00420.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07662.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3529"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e00927"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3411"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:15:40Z","timestamp":1696198540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/tid.12098"],"URL":"https:\/\/doi.org\/10.1111\/tid.12098","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}