{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:48:39Z","timestamp":1783421319359,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,11]],"date-time":"2013-08-11T00:00:00Z","timestamp":1376179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Liver transplant recipients are managed with a range of immunosuppressive regimens that place them at heightened risk of life\u2010threatening opportunistic infections such as P<\/jats:styled-content>neumocystis jirovecii<\/jats:italic> pneumonia (PJP<\/jats:styled-content>). No routine PJP<\/jats:styled-content> prophylaxis is used at out institution. We reviewed the incidence of PJP<\/jats:styled-content> in this cohort of unprophylaxed liver transplant recipients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined all liver transplants performed between J<\/jats:styled-content>anuary 2000 and J<\/jats:styled-content>anuary 2012 in I<\/jats:styled-content>reland's N<\/jats:styled-content>ational L<\/jats:styled-content>iver T<\/jats:styled-content>ransplant C<\/jats:styled-content>entre, S<\/jats:styled-content>t. V<\/jats:styled-content>incent's U<\/jats:styled-content>niversity H<\/jats:styled-content>ospital, D<\/jats:styled-content>ublin. Cases were identified through a computerized database and through the histopathology and microbiology registration system. The diagnosis of PJP<\/jats:styled-content> was confirmed by identification of P<\/jats:styled-content>neumocystis<\/jats:italic> cysts in bronchoalveolar lavage (BAL<\/jats:styled-content>) fluid or on autopsy specimens using G<\/jats:styled-content>rocott\u2013G<\/jats:styled-content>omori methenamine\u2010silver nitrate or modified W<\/jats:styled-content>right\u2013G<\/jats:styled-content>iemsa staining methods.<\/jats:p><\/jats:sec>Results<\/jats:title>During the study period, 687 liver transplants were performed. We found 7 cases of PJP<\/jats:styled-content> with an incidence rate of 0.84 per 1000 person transplant years. Five cases occurred within 12\u00a0months of transplant with 2 cases occurring at 56 and 60\u00a0months, respectively. Two cases were diagnosed at postmortem; 1 previously had negative cytology from BAL<\/jats:styled-content>, while the other could not be bronchoscoped because of rapid deterioration in the clinical condition. Three of the 5 treated patients died.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The incidence of PJP<\/jats:styled-content> in this cohort was very low, but the case fatality rate was high. Two cases occurred well after the usual recommended period of prophylaxis. In institutions with a very low risk of infection, targeted rather than universal prophylaxis may be reasonable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12117","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:30:04Z","timestamp":1376281804000},"page":"510-515","source":"Crossref","is-referenced-by-count":16,"title":["Low incidence of P<\/scp>neumocystis jirovecii<\/i> pneumonia in an unprophylaxed liver transplant cohort"],"prefix":"10.1111","volume":"15","author":[{"given":"S.","family":"Sarwar","sequence":"first","affiliation":[{"name":"Liver Unit St. Vincent's University Hospital Ireland and University College, Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Carey","sequence":"additional","affiliation":[{"name":"Liver Unit St. Vincent's University Hospital Ireland and University College, Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Hegarty","sequence":"additional","affiliation":[{"name":"Liver Unit St. Vincent's University Hospital Ireland and University College, Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Liver Unit St. Vincent's University Hospital Ireland and University College, Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03126.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.770-782.2004"},{"key":"e_1_2_5_4_1","unstructured":"BlumbergE LaRosaL.University of Pennsylvania Medical Center guidelines for antibiotics use. 2005. 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