{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:11:09Z","timestamp":1784027469596,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In lung transplant recipients (<jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>s), severe clinical complications, such as microbial infections of the lung or transplant rejection, may occur. Surfactant protein D (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D) is a C\u2010type lectin that is mainly produced in alveolar type II cells. Plasma <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D levels are usually low, but may increase when the lung\u2013blood barrier is impaired. In this study, we analyzed whether plasma <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D concentrations reflect rejection or infection of the lung allograft. An enzyme\u2010linked immunosorbent assay was used to measure <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D levels in plasma samples from 58 <jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>s during intervals without pathologic respiratory findings and during episodes of acute cellular rejection (<jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>), microbial colonization, and microbial pneumonia. Median plasma <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D levels were significantly increased during episodes of microbial pneumonia, but not in the absence of pathologic respiratory findings, during microbial colonization, or during <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> up to grade A2\u2013A3 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). During pneumonia, an increased plasma <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D level was detected in 60% of <jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>s and this was further associated with a significantly higher risk for the patients to develop stage III bronchiolitis obliterans syndrome (<jats:styled-content style=\"fixed-case\">BOS<\/jats:styled-content> III) or to die within the subsequent 6\u00a0months after pneumonia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0093). All patients with a plasma <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D level of &gt;300\u00a0ng\/mL during pneumonia developed BOS III and\/or died within 6\u00a0months of follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The determination of <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010D levels in plasma during pneumonia in <jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>s may be of prognostic value and warrants further evaluation.<\/jats:p>","DOI":"10.1111\/tid.12132","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T06:25:00Z","timestamp":1379053500000},"page":"645-651","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of plasma surfactant protein D levels in lung transplant recipients"],"prefix":"10.1111","volume":"15","author":[{"given":"I.","family":"Bejvl","sequence":"first","affiliation":[{"name":"Department of Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Weseslindtner","sequence":"additional","affiliation":[{"name":"Department of Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Strassl","sequence":"additional","affiliation":[{"name":"Department of Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jaksch","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kundi","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Klepetko","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Medical University of Vienna Vienna 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