{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:23Z","timestamp":1791308663518,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>)\u2010associated hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) is a severe complication after hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Cidofovir (<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>) has emerged as an effective agent for the treatment of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> nephropathy, but its use for <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients has not yet been established as a standard therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and methods<\/jats:title><jats:p>We retrospectively investigated the efficacy and safety of <jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content> therapy for patients with <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> at a single institution and analyzed the clinical management outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2009 to <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2011, 12 patients developed <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> at a median of 37\u00a0days after transplant (range 15\u201359\u00a0days). The cumulative incidence was 9% and the median peak of the urine <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> load was 2.5\u00a0\u00d7\u00a010<jats:sup>10<\/jats:sup> copies\/mL (range 1.4\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\u20131.2\u00a0\u00d7\u00a010<jats:sup>11<\/jats:sup> copies\/mL). Eleven patients received intravenous <jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content> (5\u00a0mg\/kg\/dose, with probenecid), whereas 1 patient received <jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content> (5\u00a0mg\/kg\/dose, without probenecid) intravesically. The median duration of therapy was 25\u00a0days (range 9\u201373\u00a0days), and a median of 2 doses was given (range 1\u20134). A reduction of \u22651 log in the <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> load was found in 11 patients, while 1 patient did not have any significant change in <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> load. Clinical improvement was observed in all cases, and no HC\u2010related death was observed. <jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>\u2010related toxicity occurred in 1 patient (8%) and spontaneously resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content> appears to be an effective and safe treatment for <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients, but prospective trials are warranted to support its use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12136","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T06:26:08Z","timestamp":1379053568000},"page":"569-574","source":"Crossref","is-referenced-by-count":52,"title":["Treatment of 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Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.\u2010G.","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics College of Medicine The Catholic University of Korea Seoul 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