{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:20:55Z","timestamp":1782976855520,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The burden of enterococcal infections has increased over the last decades with vancomycin\u2010resistant enterococci (<jats:styled-content style=\"fixed-case\">VRE<\/jats:styled-content>) being a major health problem. Solid organ transplantation is considered as a risk factor. However, little is known about the relevance of enterococci in solid organ transplantation recipients in areas with a low<jats:styled-content style=\"fixed-case\">VRE<\/jats:styled-content>prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the epidemiology of enterococcal events in patients followed in the Swiss Transplant Cohort Study between May 2008 and September 2011 and analyzed risk factors for infection, aminopenicillin resistance, treatment, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1234 patients, 255 (20.7%) suffered from 392 enterococcal events (185 [47.2%] infections, 205 [52.3%] colonizations, and 2 events with missing clinical information). Only 2 isolates were<jats:styled-content style=\"fixed-case\">VRE<\/jats:styled-content>. The highest infection rates were found early after liver transplantation (0.24\/person\u2010year) consisting in 58.6% of<jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterococcus faecium<\/jats:italic>. The highest colonization rates were documented in lung transplant recipients (0.33\/person\u2010year), with 46.5%<jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.\u00a0faecium<\/jats:italic>. Age, prophylaxis with a betalactam antibiotic, and liver transplantation were significantly associated with infection. Previous antibiotic treatment, intensive care unit stay, and lung transplantation were associated with aminopenicillin resistance. Only 4\/205 (2%) colonization events led to an infection. Adequate treatment did not affect microbiological clearance rates. Overall mortality was 8%; no deaths were attributable to enterococcal events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Enterococcal colonizations and infections are frequent in transplant recipients. Progression from colonization to infection is rare. Therefore, antibiotic treatment should be used restrictively in colonization. No increased mortality because of enterococcal infection was noted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12168","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T11:37:44Z","timestamp":1387193864000},"page":"26-36","source":"Crossref","is-referenced-by-count":44,"title":["Impact of enterococcal colonization and infection in solid organ transplantation recipients from the Swiss Transplant Cohort Study"],"prefix":"10.1111","volume":"16","author":[{"given":"E.","family":"Bucheli","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kralidis","sequence":"additional","affiliation":[{"name":"Basel Institute for Clinical Epidemiology &amp; Biostatistics University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Boggian","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Hygiene Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cusini","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases Inselspital Bern University Hospital and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garzoni","sequence":"additional","affiliation":[{"name":"Clinic of Internal Medicine &amp; Infectious Diseases Clinica Luganese Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Manuel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service University Hospital of Lausanne (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.A.","family":"Meylan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service University Hospital of Lausanne (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van Delden","sequence":"additional","affiliation":[{"name":"Service of Transplantation Department of Surgery University Hospital Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Children's Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Koller","sequence":"additional","affiliation":[{"name":"Basel Institute for Clinical Epidemiology &amp; Biostatistics University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Weisser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Swiss Transplant Cohort Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.1.46"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn390"},{"issue":"2","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1128\/AAC.41.2.494","article-title":"Change in prevalence and antibiotic resistance of Enterococcus species isolated from blood cultures over an 8\u2010year period","volume":"41","author":"Iwen PC","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0702.010205"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg305"},{"key":"e_1_2_6_7_1","unstructured":"Schweizerisches Zentrum f\u00fcr Antibiotikaresistenzen. 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