{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:00:47Z","timestamp":1770436847817,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to identify risk factors associated with pre\u2010transplant fecal carriage of extended\u2010spectrum \u03b2\u2010lactamase (<jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>)\u2010producing <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacteriaceae in liver transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Over a 3\u2010year period (January 2009\u2013December 2011), 317 patients who underwent liver transplantation were screened preoperatively for fecal carriage of <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacteriaceae. Risk factors for fecal carriage were investigated by univariate analysis and stepwise logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 317 patients screened, 50 (15.7%) harbored an <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing isolate. Previous infection with an <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing organism had developed during the last 6\u00a0months in 20% of fecal carriers versus in none of the non\u2010carriers. Other variables associated with fecal carriage were a model for end\u2010stage liver disease score \u226525, pre\u2010transplant stay in the intensive care unit \u226548\u00a0h, hospital stay \u226510\u00a0days in the last 6\u00a0months, a history of spontaneous bacterial peritonitis (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>), exposure to a \u03b2\u2010lactam agent in the last month, and prophylaxis with norfloxacin. Independent predictors of fecal carriage in the multivariate logistic regression model were exposure to a \u03b2\u2010lactam agent in the month preceding transplantation (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a07.8, confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]\u00a0=\u00a04\u201315.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and a history of <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.4, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.1\u20134.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous infection with an <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing isolate, recent exposure to a \u03b2\u2010lactam agent, and a history of <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> are risk factors for preoperative fecal carriage of <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacteriaceae in liver transplant recipients. Patients at risk of fecal carriage should receive intraoperative prophylaxis and, when necessary, empiric postoperative antimicrobial treatment that includes coverage for these organisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12169","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T11:37:38Z","timestamp":1387193858000},"page":"84-89","source":"Crossref","is-referenced-by-count":43,"title":["Risk factors associated with preoperative fecal carriage of extended\u2010spectrum \u03b2\u2010lactamase\u2010producing <scp>E<\/scp>nterobacteriaceae in liver transplant recipients"],"prefix":"10.1111","volume":"16","author":[{"given":"F.","family":"Bert","sequence":"first","affiliation":[{"name":"Service de Microbiologie H\u00f4pital Beaujon AP\u2010HP Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Larroque","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie et Recherche clinique H\u00f4pital Beaujon AP\u2010HP Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Dondero","sequence":"additional","affiliation":[{"name":"Service de Chirurgie digestive H\u00f4pital Beaujon AP\u2010HP Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Durand","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie H\u00f4pital Beaujon AP\u2010HP Clichy France"},{"name":"Centre de Recherche Biom\u00e9dicale Bichat\u2010Beaujon (CRB3) INSERM U773 Paris France"},{"name":"Facult\u00e9 de M\u00e9decine D. Diderot Universit\u00e9 Paris VII Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Paugam\u2010Burtz","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine D. Diderot Universit\u00e9 Paris VII Paris France"},{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation H\u00f4pital Beaujon AP\u2010HP Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Belghiti","sequence":"additional","affiliation":[{"name":"Service de Chirurgie digestive H\u00f4pital Beaujon AP\u2010HP Clichy France"},{"name":"Facult\u00e9 de M\u00e9decine D. 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