{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:24:24Z","timestamp":1765545864961},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We retrospectively analyzed 80 instances of varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) disease in 72 patients who underwent allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) and examined the clinical differences between localized and disseminated disease. Risk factors for developing <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> dissemination were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 80 instances, 54 instances were localized diseases and 26 were disseminated diseases. Patient characteristics did not differ significantly between the 2 groups, except for the first\u2010line therapy and the duration from symptom onset to treatment. In the disseminated group, intravenous acyclovir was used as the first\u2010line therapy more frequently, and more time elapsed before beginning antiviral therapy compared with the localized group. In multivariate analyses, the duration from symptom onset to treatment was identified as an independent risk factor that significantly affected the development of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> dissemination. Gender, total body irradiation, and chronic graft\u2010versus\u2010host disease, of which the latter 2 factors were reported as risk factors for the development of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> disease after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, did not affect the development of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> dissemination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection or reactivation may easily progress to viremia with delayed use of antiviral agents and may result in <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> dissemination in immunocompromised patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12181","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T06:48:25Z","timestamp":1390200505000},"page":"195-202","source":"Crossref","is-referenced-by-count":16,"title":["Clinical features and risk factors for developing varicella zoster virus dissemination following hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"Y.","family":"Umezawa","sequence":"first","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kakihana","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Oshikawa","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Doki","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo 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