{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T21:07:48Z","timestamp":1792357668192,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite routine use of umbilical cord blood (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>) grafts as stem cell source for allogeneic stem cell transplantations, much remains unknown regarding their cell composition and correlation with clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed material from 30 <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> units used for allogeneic hematopoietic stem cell transplantation by multicolor flow cytometry. Phenotypic data were correlated with various clinical outcomes such as survival, graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>), relapse, rejection, viral reactivation, and bacteremia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that above\u2010median frequencies of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>69+ T cells, na\u00efve <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>127+ B cells in the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> graft were each associated with significantly improved patient survival. Moreover, a statistically significant correlation was seen between higher levels of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>94+ T cells and herpes simplex virus and varicella zoster virus reactivation post transplantation. A similar correlation was seen for the frequency of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95+ cells in total <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+, as well as <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T\u2010cell subsets, and viral reactivation. Finally, a higher frequency of na\u00efve <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells was associated with the incidence of acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study highlights the importance of further exploration of graft composition before <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> transplantation as a tool for risk prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12182","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T05:59:32Z","timestamp":1390543172000},"page":"203-212","source":"Crossref","is-referenced-by-count":11,"title":["Cord blood graft composition impacts the clinical outcome of allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"H.","family":"Wikell","sequence":"first","affiliation":[{"name":"Division of 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