{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:00:26Z","timestamp":1775714426596,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium<\/jats:italic> infections following solid organ transplantation have been performed in the era of induction immunosuppression and widespread antifungal prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center, retrospective study of transplant recipients from 2000 through 2010 who had a positive <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium<\/jats:italic> culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 27 patients, 67% (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) and 33% (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) were infected with <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium apiospermum<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium prolificans<\/jats:italic>, respectively. A total of 67% received induction immunosuppression and 74% received prior antifungal therapy. Isolates were broadly resistant to antifungals. Of these patients, 59% (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) were colonized by <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium<\/jats:italic>, and 41% (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) had disease (scedosporiosis). No significant clinical differences were seen between species. Colonization occurred exclusively in the lungs of lung transplant recipients (<jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>). Scedosporiosis followed lung transplantation in 55%, and other organ transplants (multivisceral [18%]; and heart, liver, small intestine [9% each]) in 45%. Scedosporiosis was preceded by colonization in 36%. Diseases included pneumonia (64%), mediastinitis (18%), and fungemia\/disseminated infections (18%). The 6\u2010month outcomes were death in 55%, progression in 18%, stability in 9%, and resolution in 18%. Patients who died had earlier onset scedosporiosis post transplant (median: 80.5 vs. 1388\u00a0days; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), and were more likely to have mediastinitis or disseminated infections than pneumonia (100% vs. 29%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). The 3 patients who developed scedosporiosis &gt;1\u00a0year post transplant survived. All patients who survived were treated with a voriconazole\u2010containing regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content> were most susceptible to <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cedosporium<\/jats:italic> colonization and scedosporiosis, particularly within the lungs. Death was common with scedosporiosis in the first year after all types of organ transplants, consistent with profound immunosuppression and antifungal resistance, but not encountered thereafter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12244","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T16:27:34Z","timestamp":1403627254000},"page":"578-587","source":"Crossref","is-referenced-by-count":64,"title":["Epidemiology, clinical manifestations, and outcomes of <i><scp>S<\/scp>cedosporium<\/i> infections among solid organ transplant recipients"],"prefix":"10.1111","volume":"16","author":[{"given":"L.S.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.K.","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Infectious Diseases Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Clancy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01208.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780600752507"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-07"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.10.4930-4942.2005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01122-07"},{"issue":"3","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/jcm.26.3.498-503.1988","article-title":"Scedosporium inflatum, an emerging pathogen","volume":"26","author":"Salkin IF","year":"1988","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249118"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200209000-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00298-5"},{"issue":"3","key":"e_1_2_6_11_1","first-page":"184","article-title":"Invasive infection caused by Pseudallescheria boydii in an immunocompetent patient","volume":"13","author":"Bibashi E","year":"2009","journal-title":"Hippokratia"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01840-09"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.01.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2011.04.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02110.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.06.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.30402.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/426445"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.03.023"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9352-x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.714"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.954-958.2001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.13"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01388-07"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0108-6"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.6.890"},{"issue":"1","key":"e_1_2_6_29_1","first-page":"83","article-title":"Scedosporium apiospermum brain abscess treated with surgery and voriconazole. 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