{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:49:07Z","timestamp":1791161347346,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 20\u2010year\u2010old woman, with renal transplant complicated by recurrence of focal segmental glomerulosclerosis and post\u2010transplant lymphoproliferative disorder, presented nearly 2\u00a0years after transplantation with fever, conjunctivitis, and sinus congestion. She was found to have severe adenovirus (<jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content>)\u2010induced granulomatous interstitial nephritis, confirmed by immunohistochemical staining for <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> in the renal biopsy, without urinary symptoms, hematuria, or laboratory evidence of a change in allograft function. Fever, upper respiratory tract symptoms, and evidence of adenoviral infection in the allograft resolved with decreased immunosuppression and treatment with cidofovir and intravenous immunoglobulin. Creatinine rose during treatment and remained elevated, possibly related to cidofovir nephrotoxicity. Despite therapy and continued reduction in immunosuppression, asymptomatic low\u2010level viremia persisted for a year. In renal transplant patients with <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> infection, allograft involvement should be highly suspected even without overt urinary symptoms or laboratory evidence of allograft dysfunction. Demonstration of allograft involvement may prompt alternative management that could limit continued allograft infection. No clear recommendations exist for management of asymptomatic <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> viremia in solid organ transplant patients.<\/jats:p>","DOI":"10.1111\/tid.12248","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T05:01:49Z","timestamp":1403758909000},"page":"648-652","source":"Crossref","is-referenced-by-count":30,"title":["Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia"],"prefix":"10.1111","volume":"16","author":[{"given":"A.M.","family":"Lachiewicz","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.K.","family":"Derebail","sequence":"additional","affiliation":[{"name":"UNC Kidney Center Division of Nephrology and Hypertension Department of Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12112"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft036"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-005-0722-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/380450"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00052-07"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03479.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis689"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01033.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703798"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn495"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.06.059"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00452.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010090941"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:00:43Z","timestamp":1695567643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/tid.12248"],"URL":"https:\/\/doi.org\/10.1111\/tid.12248","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}