{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:50:26Z","timestamp":1789908626906,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplant recipients are at risk for life\u2010threatening infections, which may affect the long\u2010term prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included all kidney transplant recipients admitted for sepsis, severe sepsis, or septic shock to the medical intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>) of the Saint\u2010Louis Hospital, Paris, France, between 2000 and 2010. The main objective was to identify factors associated with survival without graft impairment 90\u00a0days after <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available for 83 of 100 eligible patients. The main sites of infection were the lungs (54%), urinary tract (24%), and bloodstream (22%). Among documented infections (55\/83), 80% were bacterial. Fungal infections were more common among patients transplanted after 2005 (5% vs. 23%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Mechanical ventilation was used in 46 (56%) patients, vasopressors in 39 (47%), and renal replacement therapy (<jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>) in 34 (41%). In\u2010hospital and day\u201090 mortality rates were 20% and 22%, respectively. On day 90, among the 65 survivors, 39 (47%) had recovered their previous graft function and 26 (31%) had impaired graft function, including 16 (19%) who were dependent on <jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>. Factors independently associated with day\u201090 survival and graft function recovery were baseline serum creatinine (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] for a 10\u00a0\u03bcmol\/L increase 0.94, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.88\u20131.00) and cyclosporine therapy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.30, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.11\u20130.79).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sepsis was chiefly related to bacterial pneumonia or urinary tract infection. <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>neumocystis jirovecii<\/jats:italic> was the leading opportunistic agent, with a trend toward an increase over time. Infections often induced severe graft function impairment. Baseline creatinine and cyclosporine therapy independently predicted the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12249","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T05:17:15Z","timestamp":1403759835000},"page":"588-596","source":"Crossref","is-referenced-by-count":47,"title":["Severe infections requiring intensive care unit admission in kidney transplant recipients: impact on graft outcome"],"prefix":"10.1111","volume":"16","author":[{"given":"N.","family":"Bige","sequence":"first","affiliation":[{"name":"Medical Intensive Care Unit Saint\u2010Louis University Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zafrani","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Saint\u2010Louis University Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Biostatistics Department Saint\u2010Louis University Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010N.","family":"Peraldi","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation Department Saint\u2010Louis University Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Snanoudj","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes &amp; 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