{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:26:22Z","timestamp":1773393982163,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Prognostic data on survival of hepatitis B surface antigen\u2010positive (HB<\/jats:styled-content>sAg+) recipients and of hepatitis B core antibody\u2010positive (HB<\/jats:styled-content>cAb+) donors are limited in the thoracic transplantation (TT<\/jats:styled-content>) cohort. Improved understanding of risks could potentially expand the recipient and donor pools.<\/jats:p><\/jats:sec>Methods<\/jats:title>Post\u2010hoc analysis of limited\u2010access dataset of the United Network for Organ Sharing database from January 2000\u2013September 2010 was performed. Analyses were performed for all TT<\/jats:styled-content>, including single and bilateral lung, orthotopic heart, and simultaneous heart\u2010lung transplants. The primary analyzed outcome was overall survival. A Cox proportional multivariate hazards model was used to adjust for significant risk predictors.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 24,817 patients included, 426 recipients were HB<\/jats:styled-content>sAg+, of whom 106 (25%) died during a mean follow\u2010up of 3.6\u00a0years. On multivariate analysis, recipient HB<\/jats:styled-content>sAg+ (hazard ratio [HR<\/jats:styled-content>]\u00a0=\u00a00.88, 95% confidence interval [CI<\/jats:styled-content>]: 0.69\u20131.32; P<\/jats:italic>\u00a0=\u00a00.80), and donor HB<\/jats:styled-content>cAb+ (HR<\/jats:styled-content>\u00a0=\u00a00.91, 95% CI<\/jats:styled-content>: 0.68\u20131.22; P<\/jats:italic>\u00a0=\u00a00.53) were not associated with increased overall mortality in the entire TT<\/jats:styled-content> cohort, with similar results for each individual transplant cohort. Unadjusted survival analysis using Kaplan\u2013Meier curves in individual transplant cohorts did not show significant differences between HB<\/jats:styled-content>sAg+ and HB<\/jats:styled-content>sAg\u2212 recipients. No statistically significant differences were found between causes of mortality in the 2 groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HB<\/jats:styled-content>sAg+ status of recipients or HB<\/jats:styled-content>cAb+ status of donors does not significantly affect overall survival of TT<\/jats:styled-content> recipients. These data add to the scant literature on this subject and could potentially increase the donor and recipient pools.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12256","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T02:31:10Z","timestamp":1404268270000},"page":"597-604","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic implications of recipient or donor hepatitis B seropositivity in thoracic transplantation: analysis of 426 hepatitis B surface antigen\u2010positive recipients"],"prefix":"10.1111","volume":"16","author":[{"given":"P.","family":"Manickam","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology William Beaumont Hospital Royal Oak Michigan USA"},{"name":"Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Krishnamoorthi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Cappell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology William Beaumont Hospital Royal Oak Michigan USA"},{"name":"Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18420"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02146.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.06.068"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b4e1fd"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000165858.86067.a2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199607270-00025"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00142-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)02666-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352871"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199501270-00014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.025"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040683"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.09.094"},{"key":"e_1_2_6_16_1","unstructured":"International Society for Heart and Lung Transplantation (ISHLT).Slide entitled: Adult lung transplantation Kaplan\u2010Meier survival by era. In: Overall lung and adult lung transplantation statistics. Available at:http:\/\/www.ishit.org\/registries\/slides.asp?slides=heartLungRegistry(Accessed February 25 2014)."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02613.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt501"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:59:57Z","timestamp":1695567597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/tid.12256"],"URL":"https:\/\/doi.org\/10.1111\/tid.12256","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}