{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:50:16Z","timestamp":1774482616084,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIAID","award":["5U19AI090871-02"],"award-info":[{"award-number":["5U19AI090871-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Recurrent C<\/jats:styled-content>lostridium difficile<\/jats:italic> infection (CDI<\/jats:styled-content>) represents a significant burden on the healthcare system and is associated with poor outcomes in hematopoietic stem cell transplant (HSCT<\/jats:styled-content>) patients. Data are limited evaluating recurrence rates and risk factors for recurrence in HSCT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>HSCT patients who developed CDI<\/jats:styled-content> between January 2010 and December 2012 were divided into 2 groups: non\u2010recurrent CDI<\/jats:styled-content> (nrCDI<\/jats:styled-content>) and recurrent CDI<\/jats:styled-content> (rCDI<\/jats:styled-content>). Risk factors for rCDI<\/jats:styled-content> were compared between groups. Rate of recurrence in HSCT<\/jats:styled-content> patients was compared to that in other hospitalized patients.<\/jats:p><\/jats:sec>Results<\/jats:title>CDI was diagnosed in 95 of 711 HSCT<\/jats:styled-content> patients (22 rCDI<\/jats:styled-content> and 73 nrCDI<\/jats:styled-content>). Recurrence rates were similar in HSCT<\/jats:styled-content> patients compared with other hospitalized patients (23.2% vs. 22.9%, P<\/jats:italic>\u00a0>\u00a00.99). Patients in the rCDI<\/jats:styled-content> group developed the index case of CDI<\/jats:styled-content> significantly earlier than the nrCDI<\/jats:styled-content> group (3.5\u00a0days vs. 7.0\u00a0days after transplant, P<\/jats:italic>\u00a0=\u00a00.05). On univariate analysis, patients with rCDI<\/jats:styled-content> were more likely to have prior history of CDI<\/jats:styled-content> and neutropenia at the time of the index CDI<\/jats:styled-content> case. Neutropenia at the time of the index CDI<\/jats:styled-content> case was the only independent predictor of rCDI<\/jats:styled-content> (78.8 vs. 34.8%, P<\/jats:italic>\u00a0=\u00a00.006) on multivariate analysis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The rate of rCDI<\/jats:styled-content> was similar between HSCT<\/jats:styled-content> and other hospitalized patients, and the majority of patients developed the index case of CDI<\/jats:styled-content> within a week of transplantation. Neutropenia at the index CDI<\/jats:styled-content> case may be associated with increased rates of rCDI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12267","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T11:12:51Z","timestamp":1405681971000},"page":"744-750","source":"Crossref","is-referenced-by-count":39,"title":["Risk factors for recurrent C<\/scp>lostridium difficile<\/i> infection in hematopoietic stem cell transplant recipients"],"prefix":"10.1111","volume":"16","author":[{"given":"A.M.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services and Clinical Sciences University of Michigan Health System and College of Pharmacy Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services and Clinical Sciences University of Michigan Health System and College of Pharmacy Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Frame","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services and Clinical Sciences University of Michigan Health System and College of Pharmacy Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Aronoff","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine University of Michigan Health System and Medical School Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services and Clinical Sciences University of Michigan Health System and College of Pharmacy Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.02.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/651066"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.10.030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1035"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis356"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/511798"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702627"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01035.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03592-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83393-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.2.384-389.1994"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(94)90021-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920009787048419"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.3.437"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis453"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:23:31Z","timestamp":1695551011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,18]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/tid.12267"],"URL":"https:\/\/doi.org\/10.1111\/tid.12267","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,18]]}}}