{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:28:59Z","timestamp":1790638139291,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30872579"],"award-info":[{"award-number":["30872579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The role of therapeutic drug monitoring (TDM<\/jats:styled-content>) of mycophenolic acid (MPA<\/jats:styled-content>) in kidney transplant recipients (KTR<\/jats:styled-content>s) is not clear. We performed a prospective cohort study to evaluate the efficiency of MPA TDM<\/jats:styled-content> in the C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 183 living\u2010related KTR<\/jats:styled-content>s were studied; 101 KTR<\/jats:styled-content>s received controlled\u2010dose mycophenolate mofetil (MMF<\/jats:styled-content>) (the CD<\/jats:styled-content> group), and 82 patients received fixed\u2010dose MMF<\/jats:styled-content> (the FD<\/jats:styled-content> group). MPA<\/jats:styled-content> exposure was measured at days 3, 7, 14, and 30 in the CD<\/jats:styled-content> group, and at day 30 in the FD<\/jats:styled-content> group. The primary endpoint was treatment failure (a composite of acute rejection, graft loss, death, or MMF<\/jats:styled-content> discontinuation) at 12\u00a0months post transplantation.<\/jats:p><\/jats:sec>Results<\/jats:title>In the CD<\/jats:styled-content> group, with a starting MMF<\/jats:styled-content> dose of 2\u00a0g\/day, approximately 35% of patients had high MPA<\/jats:styled-content> levels, which were >60\u00a0mg\u00a0\u00d7\u00a0h\/L, and mean MPA<\/jats:styled-content> levels were 59.17\u00a0mg\u00a0\u00d7\u00a0h\/L and 61.38\u00a0mg\u00a0\u00d7\u00a0h\/L for the CD<\/jats:styled-content> and FD<\/jats:styled-content> groups, respectively (P<\/jats:italic>\u00a0=\u00a00.588). After adjusting MMF<\/jats:styled-content> dose, MPA<\/jats:styled-content> exposures in the CD<\/jats:styled-content> group at day 30 were lower than those in the FD<\/jats:styled-content> group at day 30 (54.06 vs. 61.38, P<\/jats:italic>\u00a0=\u00a00.004). At month 12, the CD<\/jats:styled-content> group had fewer infections (16.8% vs. 31.7%, P<\/jats:italic>\u00a0=\u00a00.018) with no difference in treatment failure, acute rejection, diarrhea, or anemia.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>KTR<\/jats:styled-content>s can benefit from short\u2010term TDM<\/jats:styled-content> of MPA<\/jats:styled-content> in reducing infection, without increasing acute rejection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12275","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T10:12:28Z","timestamp":1407751948000},"page":"760-766","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010term therapeutic drug monitoring of mycophenolic acid reduces infection: a prospective, single\u2010center cohort study in Chinese living\u2010related kidney transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"L.","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan People's Republic of 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