{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:31:38Z","timestamp":1773160298198,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Carbapenem\u2010resistant<jats:italic>Klebsiella pneumoniae<\/jats:italic>(<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>) infections have emerged as a significant challenge in solid organ transplantation.<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>infections in other patient populations have been associated with higher mortality, when compared to infections caused by carbapenem\u2010sensitive<jats:italic>K.\u00a0pneumoniae<\/jats:italic>(<jats:styled-content style=\"fixed-case\">CSKP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate possible risk factors, clinical characteristics, and outcomes of<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>infections compared with<jats:styled-content style=\"fixed-case\">CSKP<\/jats:styled-content>infections in kidney transplant recipients (<jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively investigated 13<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>infections and 39<jats:styled-content style=\"fixed-case\">CSKP<\/jats:styled-content>infections in<jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>(2006\u20132010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>was not significantly associated with age, gender, or comorbidities.<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>infections were significantly associated with recent exposure to broad\u2010spectrum antibiotics and were more likely to have been managed on an inpatient basis and to have required source control.<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>was significantly associated with earlier mortality. Six of 13 (46%) patients with<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>infection, and none of the patients with<jats:styled-content style=\"fixed-case\">CSKP<\/jats:styled-content>infection, died within 6.5\u00a0months of infection onset. Although cases and controls did not differ significantly with respect to diabetes, all patients (100%,<jats:italic>n<\/jats:italic>\u00a0=\u00a09) who died during the study had diabetes, while 58% of the 43 survivors had diabetes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion,<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>compared with<jats:styled-content style=\"fixed-case\">CSKP<\/jats:styled-content>is associated with greater risk of mortality. Investigations on ways to better prevent<jats:styled-content style=\"fixed-case\">CRKP<\/jats:styled-content>are urgently needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12276","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T11:46:35Z","timestamp":1407239195000},"page":"775-782","source":"Crossref","is-referenced-by-count":50,"title":["Carbapenem\u2010resistant<i><scp>K<\/scp>lebsiella pneumoniae<\/i>infections in kidney transplant recipients: a case\u2013control study"],"prefix":"10.1111","volume":"16","author":[{"given":"J.","family":"Simkins","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases at Montefiore Medical Center\/Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Muggia","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases at Montefiore Medical Center\/Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.W.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.Y.","family":"Minamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases at Montefiore Medical Center\/Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12096"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70054-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq108"},{"key":"e_1_2_6_5_1","unstructured":"Centers for Disease Control and Prevention (CDC).Healthcare\u2010associated infections. 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