{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T05:40:23Z","timestamp":1717306823854},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NATCO"},{"name":"University of Wisconsin School of Pharmacy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lung transplant (LuTx) patients are routinely immunized against tetanus and diphtheria. However, few studies have been done to measure serologic immunity in the transplant population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective of this study was to compare tetanus and diphtheria antibody concentrations in LuTx vs. healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum was used from an available sample of 111 total individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a036 healthy;<jats:italic>n<\/jats:italic>\u00a0=\u00a075 LuTx). Tetanus and diphtheria antibody concentrations were measured using an enzyme\u2010linked immunosorbant assay method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference in both tetanus and diphtheria antibody concentrations was found between the groups. The median concentration of tetanus antibody was higher for healthy individuals compared with the LuTx group (3.2\u00a0IU\/mL [1.2\u20135.2 interquartile range {<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>}] vs. 1.3\u00a0IU\/mL [0.4\u20132.6<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>], respectively;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). No difference in time was found since the last tetanus\u2010diphtheria vaccine or tetanus\u2010diphtheria\u2010pertussis vaccine dose between the groups (healthy 76.5\u00a0months [16\u2013114<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] vs. LuTx 74.5\u00a0months [45\u2013118<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>];<jats:italic>P<\/jats:italic>\u00a0=\u00a00.44).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tetanus and diphtheria immunizations are recommended for LuTx patients to reduce the risk of infection. Because the LuTx group has lower antibody concentrations, further studies should investigate the possible need for more frequent tetanus and diphtheria boosters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12288","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T09:40:59Z","timestamp":1409650859000},"page":"871-877","source":"Crossref","is-referenced-by-count":5,"title":["A cross\u2010sectional study of tetanus and diphtheria antibody concentrations post vaccination among lung transplant patients compared with healthy individuals"],"prefix":"10.1111","volume":"16","author":[{"given":"K.A.","family":"Rohde","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Henriquez","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Worzella","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Hayney","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine. 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