{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:43:00Z","timestamp":1783521780376,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Infections remain important contributors to mortality in hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We studied the evolving epidemiology and trends in susceptibility of bacterial and <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>andida<\/jats:italic> isolates at an <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> center. A total of 528 <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>s in 508 patients were performed from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2001 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2010. A total of 605 isolates were eligible for study inclusion; 318 (53%) were gram\u2010positive, 268 (44%) were gram\u2010negative, and 19 (3%) were <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>andida<\/jats:italic> species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common site for isolates was blood (380 isolates, 63%). <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>taphylococcus aureus<\/jats:italic> was the most common gram\u2010positive organism (<jats:italic>n<\/jats:italic>\u00a0=\u00a0107, 34%), but trends to increasing coagulase\u2010negative staphylococci (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and vancomycin\u2010resistant <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterococcus<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were observed. <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>scherichia coli<\/jats:italic> was the most common gram\u2010negative isolate (<jats:italic>n<\/jats:italic>\u00a0=\u00a074, 28%). Fluoroquinolone resistance increased with widespread use of protocol fluoroquinolone prophylaxis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Carbapenem resistance was found in 44% of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas<\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>cinetobacter<\/jats:italic> isolates. Bloodstream infection with a multidrug\u2010resistant organism (odds ratio 3.61, 95% confidence interval: 1.40\u20139.32, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) was an independent predictor of mortality at 7\u00a0days after a positive blood culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antimicrobial resistance is an increasing problem in this vulnerable patient population, and not only has an impact on choice of empiric therapy for febrile neutropenia but also on mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12298","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T06:37:05Z","timestamp":1412836625000},"page":"887-896","source":"Crossref","is-referenced-by-count":67,"title":["Changing microbial epidemiology in hematopoietic stem cell transplant recipients: increasing resistance over a 9\u2010year period"],"prefix":"10.1111","volume":"16","author":[{"given":"N.","family":"Macesic","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.O.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Haematology Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Central Clinical School Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Haematology Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Malignant Haematology and Stem Cell Transplantation Service Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Y.","family":"Peleg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Department of Microbiology Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004383"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044097"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050078"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01169-07"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00462-11"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir257"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp244"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/430314"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1215093"},{"key":"e_1_2_6_13_1","first-page":"CD004386","article-title":"Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy","volume":"1","author":"Gafter\u2010Gvili A","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.12.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-8-80"},{"key":"e_1_2_6_16_1","unstructured":"European Conference on Infections in Leukemia.Bacterial Resistance in Haematology \u2013 ECIL 4 Study Groups & Participants. 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