{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:29Z","timestamp":1788872309613,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Pharma Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Treatment indications of new antifungals in clinical practice often deviate from the strict criteria used in controlled clinical trials. Under routine clinical conditions, beneficial and adverse effects, not previously described in clinical trials may be observed. The aim of this study was to describe customary prescription and treatment strategies of micafungin (\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A registry was set up on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ClinicalSurveys.net\">www.ClinicalSurveys.net<\/jats:ext-link>\n                      and physicians were invited to provide retrospective information on cases they had treated with\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      . Documentation comprised demographic information, underlying disease, effectiveness, safety, and tolerability of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 125 episodes of patients hospitalized between September 2009 and February 2012 were documented, of which 7 had to be excluded because of incomplete documentation. The most common risk factors of patients were hematological malignancy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0116, 98.3%) and antibiotic treatment &gt;3\u00a0days (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0115, 97.5%).\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      was administered as prophylaxis in 106 (89.9%) patients. Median duration of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      application as prophylaxis was 21\u00a0days (range: 3\u201378); 53 of the patients (50%) received a dose of 50\u00a0mg, while the other 53 (50%) received 100\u00a0mg\/day. For the different doses, prophylactic outcome was rated as success in 42 (79.2%) vs. 52 (98.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004) patients. Fifty\u2010five patients (51.9%) were treated with posaconazole before initiation of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      . Four patients (7.5%) developed a proven invasive fungal disease (\n                      <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>\n                      ) while being treated with 50\u00a0mg\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      , compared to no patient treated with 100\u00a0mg (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.118). At the end of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      prophylaxis, 24 (22.6%) patients were switched to fluconazole and 64 (60.3%) patients to posaconazole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study shows clinical effectiveness of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      prophylaxis with low rates of breakthrough fungal infections. In most cases,\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      was part of a multi\u2010modal antifungal prophylactic strategy. Investigators reported fewer proven\n                      <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>\n                      s in patients receiving therapeutic doses of\n                      <jats:styled-content style=\"fixed-case\">MCFG<\/jats:styled-content>\n                      as prophylaxis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.12305","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T01:16:54Z","timestamp":1415150214000},"page":"968-974","source":"Crossref","is-referenced-by-count":9,"title":["Different doses of micafungin for prophylaxis of invasive fungal diseases in hemato\u2010oncological high\u2010risk patients: a web\u2010based non\u2010interventional trial in four large university hospitals in\n                    <scp>G<\/scp>\n                    ermany"],"prefix":"10.1111","volume":"16","author":[{"given":"S.M.","family":"Heimann","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.G.T.","family":"Vehreschild","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital of Cologne Cologne Germany"},{"name":"German Centre for Infection Research Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Meintker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2013Hematology and Oncology University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University of Wuerzburg Medical Center Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University of Duesseldorf, Medical Faculty Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"von Bergwelt\u2010Baildon","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital of Cologne Cologne Germany"},{"name":"Center for Integrated Oncology K\u00f6ln Bonn (CIO K\u00f6ln Bonn) University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital of Cologne Cologne Germany"},{"name":"Center for Integrated Oncology K\u00f6ln Bonn (CIO K\u00f6ln Bonn) University Hospital of Cologne Cologne Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln) Cluster of Excellence\u2013Cellular Stress Responses in Aging\u2010Associated Diseases, CECAD \u2013 BMBF01KN1106 University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Vehreschild","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital of Cologne Cologne Germany"},{"name":"German Centre for Infection Research Partner Site Bonn\u2010Cologne Cologne 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