{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:07:59Z","timestamp":1762506479692},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venovenous extracorporeal membrane oxygenation (<jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>) is increasingly used in patients with respiratory failure who fail conventional treatment. Postoperative pneumonia is the most common infection after lung transplantation (40%). Imipenem is frequently used for empirical treatment of nosocomial pneumonia in the intensive care unit. Nevertheless, few data are available on the impact of <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> on pharmacokinetics, and no data on imipenem dosing during <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>. Currently, no guidelines exist for antibiotic dosing during <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> support.<\/jats:p><jats:p>We report the cases of 2 patients supported with venovenous <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> for refractory acute respiratory distress syndrome following single lung transplantation for pulmonary fibrosis, treated empirically with 1\u00a0g of imipenem intravenously every 6\u00a0h. <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacter cloacae<\/jats:italic> was isolated from the respiratory sample of Patient 1 and <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lebsiella pneumoniae<\/jats:italic> was isolated from the respiratory sample of Patient 2. Minimum inhibitory concentrations of the 2 isolated strains were 0.125 and 0.25\u00a0mg\/L, respectively. Both patients were still alive on day 28. This is the first report, to our knowledge, of imipenem concentrations in lung transplantation patients supported with <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>. This study confirms high variability in imipenem trough concentrations in patients on <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> and with preserved renal function. An elevated dosing regimen (4\u00a0g\/24\u00a0h) is more likely to optimize drug exposure, and therapeutic drug monitoring is recommended, where available. Population pharmacokinetic studies are indicated to develop evidence\u2010based dosing guidelines for <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/tid.12327","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T11:56:08Z","timestamp":1420804568000},"page":"103-105","source":"Crossref","is-referenced-by-count":16,"title":["Alveolar and serum concentrations of imipenem in two lung transplant recipients supported with extracorporeal membrane oxygenation"],"prefix":"10.1111","volume":"17","author":[{"given":"C.","family":"Welsch","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation AP\u2010HP H\u00f4pital Bichat Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Augustin","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation AP\u2010HP H\u00f4pital Bichat Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Allyn","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation AP\u2010HP H\u00f4pital Bichat Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Massias","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"},{"name":"Laboratoire de Toxicologie\u2010Pharmacocin\u00e9tique Service de Pharmacie AP\u2010HP H\u00f4pital Bichat Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Montravers","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation AP\u2010HP H\u00f4pital Bichat Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Allou","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie\u2010R\u00e9animation AP\u2010HP H\u00f4pital Bichat Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Univiversit\u00e9 Paris Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12270"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.4.561"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00498-7"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu027"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00294-06"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks435"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11679"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181961bff"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:19:01Z","timestamp":1695493141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/tid.12327"],"URL":"https:\/\/doi.org\/10.1111\/tid.12327","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]}}}