{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:59:48Z","timestamp":1789387188427,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology of and risk factors for invasive mold disease (<jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>) among allogeneic hematopoietic cell transplant (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) recipients may vary according to the region. In this study, we sought to evaluate risk factors for <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> in our patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between May 2007 and July 2009, all <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> recipients from 8 Brazilian centers were followed prospectively until 1\u00a0year post transplant. Cases of <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> were classified as early (before day +40) or late (after day +40). Patients with <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> (cases) were compared with controls (patients without <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>) using univariate and multivariate Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 345 <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> recipients, 28 <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>s were diagnosed. Risk factors for early <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> were acute myeloid leukemia (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 2.95, 95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.13\u20137.68, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and transplant with a human leukocyte antigen\u2010mismatched donor (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.18\u20139.68, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and for late <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> risk factors were lymphoma (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 8.49, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.35\u201330.68, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), cytomegalovirus reactivation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 5.51, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.15\u201326.47, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), and neutropenia (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.49, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01\u201312.13, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The variables identified in this study may help to define risk groups, and to tailor special preventive measures to patients at higher risk to develop <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12328","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T12:16:02Z","timestamp":1420805762000},"page":"7-13","source":"Crossref","is-referenced-by-count":37,"title":["Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Atalla","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University Hospital Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garnica","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Universidade Federal do Rio de Janeiro Rio de Janeiro 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