{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:25:36Z","timestamp":1787329536872,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Donors not meeting standard criteria, such as those with bacteremia, are now being used in response to the increasing need for organs for transplantation. Recommended strategies to prevent the occurrence of donor\u2010derived bacteremia include the use of directed antibiotic prophylaxis. However, this approach does not eliminate the risk of infection transmission. Similarly, the management of organ recipients from donors with infective endocarditis (<jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>) remains uncharacterized. We report 2 cases of donor\u2010derived bacterial infections in liver transplant recipients despite pathogen\u2010specific antibiotic prophylaxis. In both instances, the donors had documented <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> treated with appropriate antimicrobial therapy and clearance of bacteremia. Recipients had very distinctive clinical outcomes likely related to pathogen virulence and the extent of donor infection. Persistent infection in the transplanted liver should be suspected in organ recipients of a liver from donors with <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>, despite the absence of bacteremia at the time of death and organ procurement. For eradication, recipients may require prolonged pathogen\u2010directed antimicrobial therapy, such as is used for endovascular infections. Prompt recognition of donors with <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>, appropriate notification, and prolonged antibiotic prophylaxis are key to reducing the risk of such donor\u2010derived infections.<\/jats:p>","DOI":"10.1111\/tid.12330","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T08:34:13Z","timestamp":1421224453000},"page":"140-146","source":"Crossref","is-referenced-by-count":21,"title":["Transmission of infection to liver transplant recipients from donors with infective endocarditis: lessons learned"],"prefix":"10.1111","volume":"17","author":[{"given":"M.H.","family":"Miceli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases University of Michigan School of Medicine Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gonulalan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Pathology Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Al Fares","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint John Providence Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brown","sequence":"additional","affiliation":[{"name":"Transplant Institute Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Transplant Institute Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zervos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Alangaden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03021.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12095"},{"key":"e_1_2_5_4_1","unstructured":"WendtJA AkselrodH CohleS KaulD et\u00a0al.Transmission of methicillin\u2010resistant Staphylococcus aureus infection through solid organ transplantation. 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