{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:28Z","timestamp":1788869608868,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI099159"],"award-info":[{"award-number":["K23AI099159"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Staphylococcus aureus<\/jats:italic>\n is among the most common causes of healthcare\u2010associated infection (\n HAI<\/jats:styled-content>\n ) in the United States. Patients who have received a solid organ transplant (\n SOT<\/jats:styled-content>\n ) represent a unique population for the acquisition of\n HAI<\/jats:styled-content>\n s, given their preoperative organ failure, immunosuppression, and need for invasive procedures. However, limited literature is published on\n S.\u00a0aureus<\/jats:italic>\n infections among children with\n SOT<\/jats:styled-content>\n . We describe the epidemiology, antimicrobial susceptibility, and clinical features of\n S.\u00a0aureus<\/jats:italic>\n infections among pediatric\n SOT<\/jats:styled-content>\n recipients.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n An ongoing prospective\n S.\u00a0aureus<\/jats:italic>\n surveillance database from 2001 to 2012 was searched for infections in patients with a history of\n SOT<\/jats:styled-content>\n at Texas Children's Hospital. Medical records and antibiotic susceptibility profiles were reviewed; specific attention was applied to the time since transplantation to infection.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of the total of 696 transplants performed during the study period, 38 pediatric\n SOT<\/jats:styled-content>\n recipients developed 41\n S.\u00a0aur<\/jats:italic>\n eus infections; the highest incidence of infection was among heart recipients. Overall, the most common infectious diagnoses were skin\u2010and\u2010soft\u2010tissue infections (66.1%), followed by bacteremia (15.3%). Among isolates in\n SOT<\/jats:styled-content>\n patients, 47.5%, 16.9%, and 6.7% were resistant to methicillin, clindamycin, or mupirocin, respectively. Three infections (7.3%) occurred in the early post\u2010transplant period (<1\u00a0month), all of which were bacteremia (\n P<\/jats:italic>\n \u00a0=\u00a00.007) and all caused by methicillin\u2010susceptible\n S.\u00a0aureus<\/jats:italic>\n (\n MSSA<\/jats:styled-content>\n ). The majority of infections (90.2%) occurred in the late post\u2010transplant period (>6\u00a0months). In 10 cases (16.9%),\n S.\u00a0aureus<\/jats:italic>\n infection was associated with graft rejection during the same admission.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n S.\u00a0aureus<\/jats:italic>\n represents an important cause of morbidity in pediatric\n SOT<\/jats:styled-content>\n recipients. While the majority of infections occurred late after transplant (>6\u00a0months), those acquired in the early post\u2010transplant period were more often invasive and caused by\n MSSA<\/jats:styled-content>\n in our hospital. Physicians caring for\n SOT<\/jats:styled-content>\n recipients should be aware of the risks posed by this pathogen and the potential concomitant morbidity including graft rejection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12331","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T06:58:08Z","timestamp":1420786688000},"page":"39-47","source":"Crossref","is-referenced-by-count":12,"title":["\n S<\/scp>\n taphylococcus aureus\n <\/i>\n infections among children receiving a solid organ transplant: clinical features, epidemiology, and antimicrobial susceptibility"],"prefix":"10.1111","volume":"17","author":[{"given":"J.C.","family":"McNeil","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"},{"name":"Department of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.G.","family":"Hult\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.O.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"},{"name":"Department of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/589717"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50142"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00574.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22278"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318271c4e0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/430312"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181c767b6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/649793"},{"issue":"4","key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/jpids\/pit037","article-title":"Staphylococcus aureus infections in children with congenital heart disease","volume":"2","author":"McNeil JC","year":"2013","journal-title":"J Pediatr Infect Dis"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02707-13"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207404.50143.1e"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000078159.53132.40"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181b9a363"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318239c1fe"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0040"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00951.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.09.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.08.005"},{"key":"e_1_2_6_24_1","unstructured":"Scientific Registry of Transplant Recipients Annual Report 2011.2012. 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