{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:44:04Z","timestamp":1790844244405,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bloodstream infections (<jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>) are frequently observed after allogeneic hematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>), and could cause morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated the incidence, characteristics of, and risk factors for <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> at both pre\u2010 and post\u2010engraftment in 209 adult <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients at our institute between June 2006 and December 2013. The median age at transplantation was 45\u00a0years (range, 15\u201365). A total of 122 patients received bone marrow, 68 received peripheral blood stem cells, and 19 received umbilical cord blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidences of pre\u2010 and post\u2010engraftment <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> were 38.9% and 17.2%, respectively. Nine patients had both pre\u2010 and post\u2010engraftment <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>. In the pre\u2010 and post\u2010engraftment periods, respectively, 67.4% and 84.1% of isolates were gram\u2010positive bacteria (<jats:styled-content style=\"fixed-case\">GPB<\/jats:styled-content>), 28.3% and 11.4% were gram\u2010negative bacteria (<jats:styled-content style=\"fixed-case\">GNB<\/jats:styled-content>), and 4.3% and 4.5% were fungi. Coagulase\u2010negative staphylococci were the most commonly isolated <jats:styled-content style=\"fixed-case\">GPB<\/jats:styled-content>, while <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tenotrophomonas maltophilia<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas aeruginosa<\/jats:italic> were the most commonly isolated <jats:styled-content style=\"fixed-case\">GNB<\/jats:styled-content>. Pre\u2010engraftment <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> was associated with an increased risk of death. Overall survival at day 180 for patients with or without pre\u2010engraftment <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> was 70.0% and 82.7%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Risk factors for <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> in the pre\u2010engraftment period were the interval between diagnosis and transplantation (261\u00a0days or more), engraftment failure, and high\u2010risk disease status at <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in a multivariate analysis. No significant risk factor for <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> in the post\u2010engraftment period was identified by a univariate analysis. These findings may be useful for deciding upon empiric antibacterial treatment for <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12345","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T15:28:58Z","timestamp":1421076538000},"page":"56-65","source":"Crossref","is-referenced-by-count":71,"title":["Risk factors for pre\u2010 and post\u2010engraftment bloodstream infections after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Division of Hematology Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Division of Hematology Saitama Medical Center Jichi Medical University Saitama 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