{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:29:29Z","timestamp":1781522969288,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"F. L\u00f3pez-Medrano is partially supported by a grant from the Research Intensification Programme of the Instituto de Investigaci\u00f3n Hospital 12 de Octubre (i+12).","award":["2014"],"award-info":[{"award-number":["2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Safety concerns have been raised about the use of adjuvanted vaccines after kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 65 kidney transplant (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) recipients who received \u22651 dose of influenza vaccine (pandemic or seasonal) during the 2009\u20132010 campaign. Participants were classified into 2 groups: those who received a squalene\u2010based <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>03\u2010 or <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>59\u2010adjuvanted vaccine (\u201cadjuvanted vaccination\u201d [<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>] group, <jats:italic>n<\/jats:italic>\u00a0=\u00a037) and those who exclusively received non\u2010adjuvanted vaccines (\u201cnon\u2010adjuvanted vaccination\u201d [<jats:styled-content style=\"fixed-case\">NAV<\/jats:styled-content>] group, <jats:italic>n<\/jats:italic>\u00a0=\u00a028). Primary outcomes included occurrence of biopsy\u2010proven acute graft rejection (<jats:styled-content style=\"fixed-case\">BPAR<\/jats:styled-content>) and graft function at months 6 and 12 after vaccination. Patients were followed up until graft loss, death, or October 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four episodes of <jats:styled-content style=\"fixed-case\">BPAR<\/jats:styled-content> occurred during post\u2010vaccination follow\u2010up, with no differences between the <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NAV<\/jats:styled-content> groups, in terms of cumulative incidence (5.4% vs. 7.1%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.581), incidence rate (0.22 vs. 0.18 episodes per 1000 transplant\u2010days; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.950), or occurrence of severe episodes (T\u2010cell\u2010mediated <jats:styled-content style=\"fixed-case\">BPAR<\/jats:styled-content> of grade \u22652a) (2.7% vs. 3.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.680). No between\u2010group differences were seen in graft function after vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjuvanted influenza vaccination in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients seems to be safe regarding graft outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12355","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T07:35:53Z","timestamp":1425281753000},"page":"314-321","source":"Crossref","is-referenced-by-count":7,"title":["Impact of squalene\u2010based adjuvanted influenza vaccination on graft outcome in kidney transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lumbreras","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Arrazola","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"L\u00f3pez\u2010Medrano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"de Juanes","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Aguado","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i + 12) School of Medicine Universidad Complutense Madrid 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