{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:53:32Z","timestamp":1777560812113,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FAPESP-Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of bloodstream infection (<jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>) varies according to the transplanted organ. Mortality can be as high as 24%, with a significant impact on graft survival. Transplantation is a risk factor for multidrug\u2010resistant (<jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>) organisms, but comparison with a non\u2010transplanted population in a single large cohort has not been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective nationwide study (16 centers) reporting data on 2364 monomicrobial nosocomial <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s, comparing 83 episodes in solid organ transplant patients with 2447 <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s occurring in the general hospital population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of groups of infecting organisms (gram\u2010positive, gram\u2010negative, and fungi) was similar between transplant patients and the general population and a similar crude mortality rate was observed (34.9% in transplant vs. 43.3% in non\u2010transplant patients). <jats:italic>Staphylococcus aureus<\/jats:italic> was the single most frequently isolated organism in both groups, and <jats:italic>Acinetobacter<\/jats:italic> species was more frequently isolated in the general population. Regarding <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> organisms, <jats:italic>Klebsiella<\/jats:italic> species, and <jats:italic>Enterobacter<\/jats:italic> species resistant to cefepime, as well as <jats:italic>Acinetobacter<\/jats:italic> species resistant to meropenem, were significantly more frequent in transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antimicrobial resistance is higher, particularly among gram\u2010negative bacteria in the transplant population, although the overall mortality rate between transplant and non\u2010transplant patients with nosocomial <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> is similar.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12356","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T08:05:20Z","timestamp":1425283520000},"page":"308-313","source":"Crossref","is-referenced-by-count":46,"title":["Nosocomial bloodstream 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