{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:56:04Z","timestamp":1787950564902,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T00:00:00Z","timestamp":1425686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010thymocyte globulin (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) has been used to prevent graft failure\/rejection in the setting of allogeneic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) for hemoglobinopathies; however, epidemiology data for transplant\u2010related infections in this population are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively analyzed the epidemiology of bacterial, fungal, viral, and parasitic infections in a cohort of 105 children and adolescents with \u03b2\u2010thalassemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100) or sickle cell disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) who underwent allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> using human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010identical sibling (<jats:italic>n<\/jats:italic>\u00a0=\u00a096) or <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010compatible unrelated donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) in a single institution. All patients received an <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010based conditioning regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) viremia was 45.7% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 33\u201355%), developing at a median of 48 (range 12\u2013142) days without evidence of overt <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease. Herpes zoster developed in 8 patients at a median of 12\u00a0months post transplant, while 10 patients presented with late onset hemorrhagic cystitis at a median of 35\u00a0days post transplant. The cumulative incidence of bacteremia was 17.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 10.6\u201325%), occurring at a median of 74 (range 24\u2013110) days. No patient developed probable or definite invasive fungal infection. Four deaths were recorded; 2 of them were attributed to infections (toxoplasmosis and <jats:italic>Pneumocystis jirovecii<\/jats:italic> pneumonia, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of infections after allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, using an <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010containing preparative regimen, in our population of pediatric patients with hemoglobinopathies is comparable to that reported elsewhere with the use of non\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> containing regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12358","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T13:27:03Z","timestamp":1422624423000},"page":"201-207","source":"Crossref","is-referenced-by-count":7,"title":["Infectious complications following allogeneic stem cell transplantation by using anti\u2010thymocyte globulin\u2010based myeloablative conditioning regimens in children with hemoglobinopathies"],"prefix":"10.1111","volume":"17","author":[{"given":"E.","family":"Goussetis","sequence":"first","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Paisiou","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Avgerinou","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zisaki","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.J.","family":"Giamouris","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Peristeri","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia Children's Hospital, Thivon and Papadiamantopoulou Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kitra","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit Aghia Sophia 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