{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:33:52Z","timestamp":1744155232564},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Umbilical cord blood transplantation (CBT<\/jats:styled-content>) is an established alternative source of stem cells in the setting of unrelated transplantation. When compared with other sources, single\u2010unitCBT<\/jats:styled-content>(sCBT<\/jats:styled-content>) is associated with a delayed hematologic recovery, which may lead to a higher infection\u2010related mortality (IRM<\/jats:styled-content>). Co\u2010infusion with thesCBT<\/jats:styled-content>ofCD<\/jats:styled-content>34+<\/jats:sup>peripheral blood stem cells from a third\u2010party donor (TPD<\/jats:styled-content>) (sCBT<\/jats:styled-content>\u00a0+\u00a0TPDCD<\/jats:styled-content>34+<\/jats:sup>) has been shown to markedly accelerate leukocyte recovery, potentially reducing theIRM<\/jats:styled-content>. However, to our knowledge, no comparative studies have focused on severe infections andIRM<\/jats:styled-content>with these 2sCBT<\/jats:styled-content>strategies.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 148 consecutivesCBT<\/jats:styled-content>(2000\u20132010, median follow\u2010up 4.5\u00a0years) were included in a multicenter retrospective study to analyze the incidence and risk factors ofIRM<\/jats:styled-content>and severe viral and invasive fungal infections (IFI<\/jats:styled-content>s). Neutrophil engraftment occurred in 90% ofsCBT<\/jats:styled-content>(n<\/jats:italic>\u00a0=\u00a077) and 94%sCBT<\/jats:styled-content>\u00a0+\u00a0TPDCD<\/jats:styled-content>34+<\/jats:sup>(n<\/jats:italic>\u00a0=\u00a071) recipients at a median of 23 and 12\u00a0days post transplantation, respectively (P<\/jats:italic>\u00a0<\u00a00.01).<\/jats:p><\/jats:sec>Results<\/jats:title>The 4\u2010yearIRM<\/jats:styled-content>was 24% and 20%, respectively (P<\/jats:italic>\u00a0=\u00a00.7), with no differences at day +30 (5% and 4%, respectively) and day +100 (10% and 8%, respectively). In multivariate analysis early status of the underlying malignancy, cytomegalovirus (CMV<\/jats:styled-content>)\u2010seronegative recipient and highCD<\/jats:styled-content>34+<\/jats:sup>cell content in the cord blood unit before cryostorage (\u22651.4\u00a0\u00d7<\/jats:bold>\u00a0105<\/jats:sup>\/kg) were protective ofIRM<\/jats:styled-content>. Among the causes ofIRM<\/jats:styled-content>, bacterial infections andIFI<\/jats:styled-content>s were more common insCBT<\/jats:styled-content>(15% vs. 4%), whileCMV<\/jats:styled-content>disease and parasitic infections were more common in thesCBT<\/jats:styled-content>\u00a0+\u00a0TPDCD<\/jats:styled-content>34+<\/jats:sup>cohort (5% vs. 16%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These data show thatsCBT<\/jats:styled-content>supported withTPDCD<\/jats:styled-content>34+<\/jats:sup>cells results in much shorter periods of post\u2010transplant leukopenia, but the short\u2010 and long\u2010term rates ofIRM<\/jats:styled-content>were comparable to those ofsCBT<\/jats:styled-content>, presumably because immune recovery is equally delayed in both graft types.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12361","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T14:37:11Z","timestamp":1422974231000},"page":"221-233","source":"Crossref","is-referenced-by-count":9,"title":["Severe infections after single umbilical cord blood transplantation in adults with or without the co\u2010infusion ofCD<\/scp>34+<\/sup>cells from a third\u2010party donor: results of a multicenter study from the Grupo Espa\u00f1ol de Trasplante Hematopoy\u00e9tico (GETH<\/scp>)"],"prefix":"10.1111","volume":"17","author":[{"given":"R.","family":"Martino","sequence":"first","affiliation":[{"name":"Clinical Hematology Service Hospital de la Santa Creu i Sant Pau Jos\u00e9 Carreras Leukemia Research Institute Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bautista","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Parody","sequence":"additional","affiliation":[{"name":"Hospital Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Clinical Hematology Service Hospital de la Santa Creu i Sant Pau Jos\u00e9 Carreras Leukemia Research Institute Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Esquirol","sequence":"additional","affiliation":[{"name":"Clinical Hematology Service Hospital de la Santa Creu i Sant Pau Jos\u00e9 Carreras Leukemia Research Institute Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic i Provincial Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Regidor","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fores","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Garc\u00eda\u2010Marco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hospital G. 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