{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:06Z","timestamp":1791308706866,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) results in significant morbidity among hematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients. Several potential causes for <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> have been postulated, including viral infection, but definitive evidence is lacking, particularly in pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients were prospectively tested on a weekly basis for adenovirus (<jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>) by quantitative real\u2010time polymerase chain reaction in blood and urine samples. Results were correlated with the occurrence of grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV HC<\/jats:styled-content>. The odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (95% confidence interval) for <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> \u22651\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> copies\/mL of urine was 7.39 (1.52, 35.99), with a <jats:italic>P<\/jats:italic>\u2010value of 0.013. Those with acute graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content>) also had higher odds of developing <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, with an <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> of 5.34. Given a 20% prevalence rate of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, positive and negative predictive values of 29% and 95% were seen with a cutoff of 10<jats:sup>9<\/jats:sup> copies\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia did not reach significance as a risk factor for development of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). Only 8 patients showed <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> viruria and 7 showed <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> viremia; all had low viral loads and 4 had no evidence of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in pediatric <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> is correlated most strongly to elevated urinary viral load of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> and to <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content>, but less strongly to <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12364","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T07:04:53Z","timestamp":1423033493000},"page":"234-241","source":"Crossref","is-referenced-by-count":43,"title":["Risk factors for hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"R.T.","family":"Hayden","sequence":"first","affiliation":[{"name":"Pathology Department St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gu","sequence":"additional","affiliation":[{"name":"Pathology Department St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Biostatistics Department St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lovins","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation &amp; Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kasow","sequence":"additional","affiliation":[{"name":"Bone Marrow and Stem Cell Transplant Program University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Woodard","sequence":"additional","affiliation":[{"name":"Genentech, Inc. 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