{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:05Z","timestamp":1790146385170,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, a platform of T\u2010cell replete haploidentical hematopoietic stem cell transplantation (haplo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) using post\u2010transplant cyclophosphamide (Cy) has shown high reproducibility and acceptable safety profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This prospective cohort analysis allowed us to collect data on infections among 70 consecutive recipients of haplo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> affected by various hematologic malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up of 23\u00a0months, cumulative incidence of viral infections was 70% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 59\u201381) at 100\u00a0days and 77% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 67\u201387) at 1\u00a0year; 35 of 65 patients at risk had <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> reactivation (54%) and the rate of polyomavirus\u2010virus\u2010associated cystitis was 19% (13\/70). Cumulative incidence of bacterial and fungal infections at 1\u00a0year were 63% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 51\u201375) and 12% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4\u201319), respectively. Of note, only 1 invasive fungal infection occurred beyond 1\u00a0year after transplant (day +739).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, despite a high rate of viral infections in the early period, present data suggest a satisfactory infectious profile after T\u2010cell replete haplo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> using post\u2010transplant Cy. These results may help clinicians to improve both prophylactic and therapeutic antimicrobial strategies in this emerging haploidentical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12365","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T07:11:14Z","timestamp":1423033874000},"page":"242-249","source":"Crossref","is-referenced-by-count":125,"title":["Infections after T\u2010replete haploidentical transplantation and high\u2010dose cyclophosphamide as graft\u2010versus\u2010host disease prophylaxis"],"prefix":"10.1111","volume":"17","author":[{"given":"R.","family":"Crocchiolo","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology Humanitas Cancer Center Humanitas Clinical and Research Center Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Humanitas Cancer Center Humanitas Clinical 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