{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:51:21Z","timestamp":1768269081526,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcus gattii<\/jats:italic> was recognized as an emerging infection in the Pacific Northwest in 2004. Out of 62 total infections in Oregon since the outbreak, 11 were in solid organ transplant (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) recipients. <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients were more likely to have disseminated disease and higher mortality than normal hosts, who mostly had isolated mass lesions. The median time from transplantation to <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.\u00a0gattii<\/jats:italic> diagnosis was 17.8\u00a0months. The primary sites of infection were lung (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), central nervous system (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), or both (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). The Oregon\u2010endemic strain, VGII (subtypes IIa and IIc) was present in 10 of 11 patients; the median fluconazole minimum inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) was 12\u00a0\u03bcg\/mL (range 2\u201332\u00a0\u03bcg\/mL) for this strain. We found <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.\u00a0gattii<\/jats:italic> infection among organ transplant recipients was disseminated at diagnosis, had low cerebrospinal fluid cryptococcal antigen titers, and was associated with an elevated fluconazole <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> and high attributable mortality.<\/jats:p>","DOI":"10.1111\/tid.12370","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T16:50:24Z","timestamp":1423759824000},"page":"467-476","source":"Crossref","is-referenced-by-count":39,"title":["<i><scp>C<\/scp>ryptococcus gattii<\/i> infection in solid organ transplant recipients: description of <scp>O<\/scp>regon outbreak cases"],"prefix":"10.1111","volume":"17","author":[{"given":"G.N.","family":"Forrest","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Portland Veterans Affairs Medical Center Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Oregon Health and Science University Portland Oregon USA"},{"name":"Oregon Health Authority Public Health Division Acute and Communicable Disease Prevention Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.E.","family":"DeBess","sequence":"additional","affiliation":[{"name":"Oregon Health Authority Public Health Division Acute and Communicable Disease Prevention Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.L.","family":"Winthrop","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Oregon Health and Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch Centers for Disease Control and Prevention Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Portland Veterans Affairs Medical Center Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.R.","family":"Cieslak","sequence":"additional","affiliation":[{"name":"Oregon Health Authority Public Health Division Acute and Communicable Disease Prevention Portland Oregon 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